Effect of grape seed on quality of life in multiple sclerosis patients


  • Amir Siahpoosh Medicinal Plants Research Center and Deparment of Pharmacognosy, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.
  • Nastaran Majdinasab Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Negin Derakhshannezhad Medicinal Plants Research Center and Deparment of Pharmacognosy, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.
  • Hamid Reza Khalili Medicinal Plants Research Center and Department of Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.
  • Alireza Malayeri Medicinal Plants Research Center and Department of Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.


Grape Seed, Multiple Sclerosis, Fatigue, Quality of Life


Objective: Multiple sclerosis is an inflammatory disease in which the myelin sheaths of the neural cells in the brain and the spinal cord are damaged. This injury affects the ability of parts of the nervous system that are responsible for communication and cause many physical and mental signs and symptoms. The grape seed which is scientifically called VitisVinifera is the native plant in southern Europe and western Asia and its extract has strong antioxidants, anti-inflammatory and neuron and nervous system protection properties. Therefore it is considered to control the free radicals and inflammation that contribute to the development and progression of MS.

Methods: The effect of grape seed extract on the fatigue control in patients was investigated as a double-blinded design. 66 patients, all treated with interferon, were randomly divided into 2 groups. The first group received placebo for the first month and the second group had grape seed capsules for one month. Fatigue was calculated based on multiple sclerosis quality of life-54 before and after the study. The results were analyzed by T-test to compare the mean in both groups and also the pair t-test was applied to compare the fatigue test score before and after the treatment in the groups.

Results: The results showed that the use of grape seed capsules significantly altered the physical and mental activity of patients with MS.

Conclusion: The existing MS drugs reduce the number of relapses, severity of disease and prevent disease progression. They have less effect on symptoms and improving performance and the quality of life along with side effects. Due to the absence of significant side effects of grape seed and its proper effect, it can be used to improve fatigue and physical and mental activity in patients.


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How to Cite

Siahpoosh, A., Majdinasab, N., Derakhshannezhad, N., Khalili, H. R., & Malayeri, A. (2018). Effect of grape seed on quality of life in multiple sclerosis patients. Journal of Contemporary Medical Sciences, 4(3). Retrieved from https://www.jocms.org/index.php/jcms/article/view/453