Effect of grape seed on quality of life in multiple sclerosis patients

  • Amir Siahpoosh Medicinal Plants Research Center and Deparment of Pharmacognosy, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.
  • Nastaran Majdinasab Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Negin Derakhshannezhad Medicinal Plants Research Center and Deparment of Pharmacognosy, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.
  • Hamid Reza Khalili Medicinal Plants Research Center and Department of Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.
  • Alireza Malayeri Medicinal Plants Research Center and Department of Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.


Objective: Multiple sclerosis is an inflammatory disease in which the myelin sheaths of the neural cells in the brain and the spinal cord are damaged. This injury affects the ability of parts of the nervous system that are responsible for communication and cause many physical and mental signs and symptoms. The grape seed which is scientifically called VitisVinifera is the native plant in southern Europe and western Asia and its extract has strong antioxidants, anti-inflammatory and neuron and nervous system protection properties. Therefore it is considered to control the free radicals and inflammation that contribute to the development and progression of MS.
Methods: The effect of grape seed extract on the fatigue control in patients was investigated as a double-blinded design. 66 patients, all treated with interferon, were randomly divided into 2 groups. The first group received placebo for the first month and the second group had grape seed capsules for one month. Fatigue was calculated based on multiple sclerosis quality of life-54 before and after the study. The results were analyzed by T-test to compare the mean in both groups and also the pair t-test was applied to compare the fatigue test score before and after the treatment in the groups.
Results: The results showed that the use of grape seed capsules significantly altered the physical and mental activity of patients with MS.
Conclusion: The existing MS drugs reduce the number of relapses, severity of disease and prevent disease progression. They have less effect on symptoms and improving performance and the quality of life along with side effects. Due to the absence of significant side effects of grape seed and its proper effect, it can be used to improve fatigue and physical and mental activity in patients.
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1.Rao SM. Neuropsychology of multiple sclerosis: a critical review. Journal of Clinical and experimental Neuropsychology. 1986;8(5):503-42.
2. Valko M., Rhodes CJ., Moncol J., Izakovic MM., Mazur M. Free radicals, metals and antioxidants in oxidative stress_induced cancer. Chemico-Biological Interaction. 2006; 160(1): 1-40.
3.Gilgun-Sherki Y, Melamed E, Offen D. The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. Journal of neurology. 2004;251(3):261-8.
4. Van Horssen J, Witte ME, Schreibelt G, De Vries HE. Radical changes in multiple sclerosis pathogenesis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2011;1812(2):141-50.

5. Jayaprakasha GK, Singh, RP, Sakariah KK. Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro. Food chemistry. 2001; 73(3): 285-290.‏

6. Pilutti LA, Greenlee TA, Motl RW, Nickrent MS, Petruzzello SJ. Effects of exercise training on fatigue in multiple sclerosis: A meta-analysis. Psychosomatic Medicine. 2013; 75(6):575-580.
7. Montealegre RR, Peces RR, Vozmediano JC, Gascueña JM, Romero EG. Phenolic compounds in skins and seeds of ten grape Vitis vinifera varieties grown in a warm climate. Journal of Food Composition and Analysis. 2006;19(6):687-93.
8. Yilmaz Y, Toledo RT. Health aspects of functional grape seed constituents. Trends in food science & technology. 2004; 15(9), 422-433.‏
9. Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seeds—biochemistry and functionality. Journal of medicinal food. 2003; 6(4), 291-299.‏
10. Chu H, Tang Q, Huang H, Hao W, Wei X. Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and and NF-kb signal pathways. Environmental toxicology and pharmacology. 2016 (41) :159-166.
11. Feng, Y., Liu, Y. M., Fratkins, J. D., & LeBlanc, M. H. Grape seed extract suppresses lipid peroxidation and reduces hypoxic ischemic brain injury in neonatal rats. Brain research bulletin.2005; 66(2): 120-127.‏
12. Balu M, Sangeetha P, Murali G., Panneerselvam C. Modulatory role of grape seed extract on age-related oxidative DNA damage in central nervous system of rats. Brain research bulletin. 2006; 68(6), 469-473.‏

13. Smith KJ, Lassmann, H. The role of nitric oxide in multiple sclerosis. The Lancet Neurology. 2002; (4): 232-241.‏

14. Kolb H., Kolb-Bachofen V. Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator? Immunology today. 1998; 19(12): 556-561.‏

15. Bi XL, Yang JY, Dong YX, Wang JM, Cui YH, Ikeshima T, Wu CF. (2005). Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia. International immunopharmacology, 2005; 5(1): 185-193.
16. Aleessa, A. S. A. J. (2017). Psycho-social and medical patterns of psychiatric disorders in multiple sclerosis patients, Baghdad-Iraq. Iraqi Journal of Public Health, 1(3).
17‏. Majdinasab N, Siahpush A, Mousavinejad S K, Malayeri A R, Sajedi S A, Bizhanzadeh P. Effect of Boswellia serrata on cognitive impairment in multiple sclerosis patients.Journal of Herbal Medicine http://dx.doi.org/10.1016/j.hermed.2016.05.003.
18. Polman C. H., Reingold S. C., Banwell B., Clanet M., Cohen J. A., Filippi M., Fujihara K., Havrdova E., Hutchinson M., Kappos L., Lublin F. D., Montalban X., O'Connor P., Sandberg-Wollheim M., Thompson A. J., Waubant E., Weinshenker B., Wolinsky J. S.. Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Annals of Neurology. 2011; 69(2): 292–302.
19. Siahpoosh A., Soleimani I. In vitro evaluation of inhibitory effect of Phoenix dactylifera bark extract on rat lipid peroxidation and blood hemolysis. Tropical Journal of Pharmaceutical Research. 2016; 15(8), 1707-1713.‏
20. Stuifbergen AK, Harrison TC. Complementary and alternative therapy use in persons with multiple sclerosis. Rehabilitation Nursing. 2003; 28(5): 141-147.
21. Goodin DS, Frohman EM, Garmany GP, Halper J, Likosky WH, Lublin FD, Silberberg DH, Stuart WH, Van den Noort S. Disease modifying therapies in multiple sclerosis. Neurology. 2002 Jan;58(2):169-78.
22. Martín R, Carvalho-Tavares J, Hernández M, Arnes M, Ruiz-Gutierrez V, Nieto ML. Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role. Biochemical pharmacology. 2010; 79(2):198-208.
23. Ghazavi A, Mosayebi G, Salehi H, Abtahi H. Effect of ethanol extract of saffron (Crocus sativus L.) on the inhibition of experimental autoimmune encephalomyelitis in C57bl/6 mice. Pakistan journal of biological sciences. 2009; 12(9):690-695.
24.Kavia RB, De Ridder D, Constantinescu CS, Stott CG, Fowler CJ. Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. Multiple Sclerosis Journal. 2010 Nov;16(11):1349-59.
25. Barnes MP. Sativex®: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain. Expert opinion on pharmacotherapy. 2006;7(5):607-15.
26. Hall W. The adverse health effects of cannabis use: what are they, and what are their implications for policy?. International Journal of drug policy. 2009; 20(6): 458-66.

27. Terra X, Montagut G, Bustos M, Llopiz N, Ardèvol A, Bladé C, Fernández-Larrea J, Pujadas G, Salvadó J, Arola L, Blay M. Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. The Journal of nutritional biochemistry. 2009;b20(3):b210-218.
28. Wang H, Xue Y, Zhang H, Huang Y, Yang G, Du M, Zhu MJ. Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10‐deficient mice. Molecular nutrition & food research. 2013; 57(12):2253-7.
29. van Oosten BW, Polman CH. Cytokines And Multiple Sclerosis. InNeurochemistry 1997 (pp. 121-124). Springer US.
30. Sun AY, Wang Q, Simonyi A, Sun GY. Resveratrol as a therapeutic agent for neurodegenerative diseases. Molecular neurobiology. 2010;41(2-3):375-83.
31. Frémont L, Belguendouz L, Delpal S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life sciences. 1999;64(26):2511-21.
32. Schirmer H, Pereira TC, Rico EP, Rosemberg DB, Bonan CD, Bogo MR, Souto AA. Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver. Molecular biology reports. 2012;39(3):3281-9.
33. Ren Z, Wang L, Cui J, Huoc Z, Xue J, Cui H, Mao Q, Yang R. Resveratrol inhibits NF-κB signaling through suppression of p65 and IB kinase activities. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2013; 8(8): 689-94.
34. Das DK, Maulik N. Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Molecular interventions. 2006; 6(1):36.
How to Cite
SIAHPOOSH, Amir et al. Effect of grape seed on quality of life in multiple sclerosis patients. Journal of Contemporary Medical Sciences, [S.l.], v. 4, n. 3, sep. 2018. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/453>. Date accessed: 24 oct. 2018.