Eremostachys Binalodensis, A Potential Therapeutic Choice for Gingival Inflammatory Wounds


  • Armin S.Hariri Oral and Maxillofacial Medicine Department, Faculty of Dentistry, Aja University of Medical Sciences, Tehran, Iran
  • Sevda Shayesteh Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
  • Parina Asgharian Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohsen Chamanara Department of Pharmacology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
  • Maryam-Sadat Sadrzadeh-Afshar Oral and Maxillofacial Medicine Department, Faculty of Dentistry, Aja University of Medical Sciences, Tehran, Iran



Eremostachys, Gingivitis, Fibroblast, Inflammation, Wound


Objectives: In this study we aimed to evaluate the effect of E. binalodensis on gingival inflammatory wounds.

Methods: In-vitro wound was induced by scratching the surface layer of human gingival fibroblasts (hGFs). Cells were pretreated with 1,10,100,1000 µg/ml of E. binalodensis methanol extract prior to 1µg/ml LPS stimulation. hGFs proliferation was assessed by MTT test. Also levels of critical inflammatory cytokines such as IL-1ð›½, IL-6 and TNF-𛼠were determined by enzyme-linked immunosorbent assay (ELISA).

Results: Wound induction was associated with secretion of IL-1β, IL-6 and TNF-α from hGFs. E. binalodensis enhanced the hGFs proliferation besides reducing the level of IL-1β, IL-6 and TNF-α in LPS-scratch-stimulated hGFs.

Conclusions: Regarding anti-inflammatory and proliferative effects of E. binalodensis on hGFs, availability and safety of it, it is suggested for enhancing the wound healing process in gingival inflammatory wounds.


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How to Cite

S.Hariri, A., Shayesteh, S., Asgharian, P., Chamanara, M., & Sadrzadeh-Afshar, M.-S. (2021). Eremostachys Binalodensis, A Potential Therapeutic Choice for Gingival Inflammatory Wounds. Journal of Contemporary Medical Sciences, 7(3), 140–144.

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