Comparison between Gingival Pyogenic Granuloma and Peripheral Giant Cell Granuloma by Immunohistochemical Detection of CD34 and Alpha Smooth Muscle Actin

Authors

  • Aween Auda Ablahad Ministry of Health, Erbil, Kurdistan Region, Iraq.
  • Ameera Kamal Khleel Department of Dentistry, Al-Hussein University College, Karbala, Iraq.
  • Jasim Almahana Department of Dentistry, Al-Hussein University College, Karbala, Iraq.

DOI:

https://doi.org/10.22317/jcms.v5i3.611

Keywords:

Pyogenic granuloma, , Peripheral giant cell granuloma, CD34, α-SMA

Abstract

Objectives: The aim of the present research was to study the clinical and the immunohistochemical expressions of CD34 and alpha smooth muscle actin (α-SMA) for gingival pyogenic granuloma in comparison with peripheral giant cell granuloma. 

 

Methods: Formalin fixed, paraffin-embedded biopsy specimens of (48) gingival pyogenic granuloma and (39) peripheral giant cell granuloma were used in the study. Immunohistochemical analysis for CD34 and α-SMA were studied in PG and PGCG.

 

Results: The mean numbers of the CD34 positive micro vessels in PGs and PGCGs were 32.58± 17.778 and 22.4±11.208 respectively. Statistical analysis showed a highly significant difference present between them (P<0.01).The mean numbers of blood vessels with vascular surrounding cells non-reactive to α-SMA in PGs and PGCGs were 3.81± 2.228 and 10.53±3.432 respectively.  Statistical analysis showed a highly significant differences present between them (p<0.01).

Conclusion: The mean number of CD34 positive micro vessels in PGs was significantly more than that of PGCG, but the mean number of  vascular surrounding cells non-reactive to α-SMA  was significantly less. This can add insight to the clinical behavior and might reflect the differences in pathogenesis of these lesions.

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Published

2019-06-26

How to Cite

Ablahad, A. A., Khleel, A. K., & Almahana, J. (2019). Comparison between Gingival Pyogenic Granuloma and Peripheral Giant Cell Granuloma by Immunohistochemical Detection of CD34 and Alpha Smooth Muscle Actin. Journal of Contemporary Medical Sciences, 5(3), 160–164. https://doi.org/10.22317/jcms.v5i3.611