Nephroprotective effect of Curcumin (Curcuma Longa) in acute nephrotoxicity in Sprague-Dawley rats
Objective: The objective of the present study was to evaluate the nephroprotective effect of curcumin in gentamicin induced-nephrotoxicity. Methods: Thirty Male Sprague-Dawley rats were used which divided into three groups, Group1 (n=10): Rats treated with distilled water plus normal saline for 12 days. Group2 (n=10): Rats treated with distilled water plus gentamicin for 12 days. Group 3(n=10): Rats treated with curcumin plus Gentamicin for 12 days. Blood urea, serum creatinine, malondialdehyde (MDA), kidney injury molecule (KIM-1) and cystatin-c were measured in both control and experimental groups. Results: Rats treated with gentamicin showed nephrotoxicity as evidence by significant elevation in serum creatinine, blood urea, KIM-1, MDA, Cystatin-C sera levels. Conclusion: Curcumin produced significant nephroprotective effect in gentamicin induced-nephrotoxicity through modulation of oxidative stress and inflammatory biomarkers.
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