Preparation of nanohybrid compound from the drugs (naproxen and cephalexin) with zinc oxide and studying biological activities against Aeromonas bacteria

Abstract

Objectives This study focus on the preparation of the compound nanoscale layers of Zinc oxide (ZnO) with naproxen and cephalexin.
Methods Ion exchange technique via sol-gel method synthesised under aqueous environment, resulted in the formation of inorganic organic
characteristics of nanohybrid by using X-ray diffraction (XRD) method and study antibacterial activity of hybrid and free compound against
some bacteria.
Results The powder X-ray diffraction showed new level for nanohybrid compounds differ from free compounds. The antibacterial results
show more nanohybrid compounds concentration increased its effectiveness against bacteria, the greater the concentration of the
compound greater is the increase in its effectiveness against bacteria inhibitory.
Conclusions The possibility of the bind of drugs (Cephalexin and Naproxen) in the preparation of nanohybrid-ZnO compound and the use
of nanocompounds as antibacterial agent in better treatment of pathogenic bacteria. And this nanocompound is more efficient from free
compounds.