An Overview of Effective Herbal and Antioxidant Compounds on Diabetes
Keywords:Diabetes, Herbal medicine, Herbal Antioxidant compounds
Objective: The aim of present study was to review the effect of herbal medicine and antioxidant compounds on diabetes.
Methods: We searched PubMed, Science Direct, Scopus, and Medline for studies published from 2000 to 2017 with using keywords of diabetes, herbal medicine, and antioxidant compounds.
Results: Various herbal medicines have been introduced to cure the diabetes. The most common types of effective compounds include flavonoids, terpenoid, carotenoids and alkaloids which are able to reduce the levels of blood sugar via increase insulin levels or reduction of intestinal uptake of glucose and regenerate pancreatic tissue through different mechanisms.
Conclusion: Herbal medicines with antidiabetic effects can give raise a field to discover drugs with herbal origin for treating the diabetes. Different herbal remedies have been known and proved that mechanism of action.
2- Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care. 2004; 27(5):1047-53.
3- Ã–ztÃ¼rk E, Arslan AK, Yerer MB, Bishayee A. Resveratrol and diabetes: A critical review of clinical studies. Biomedicine & Pharmacotherapy. 2017; 95:230-4.
4-Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stressâ€”a concise review. Saudi Pharmaceutical Journal. 2016; 24(5):547-53.
5- Sen S, Chakraborty R, Sridhar C, Reddy YS, De B. Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. International Journal of Pharmaceutical Sciences Review and Research. 2010; 3(1):91-100.
6- Reddy SS. Health outcomes in type 2 diabetes. International journal of clinical practice. Supplement. 2000 (113):46-53.
7- Chakrabarti R, Rajagopalan R. Diabetes and insulin resistance associated disorders: disease and the therapy. Current Science. 2002; 1: 1533-1538.
8- Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of diabetes and diabetes-related complications. Physical therapy. 2008; 88(11):1254-64.
9- Barroso I. Genetics of type 2 diabetes. Diabetic Medicine. 2005; 22(5): 517-35.
10- Chimen M, Kennedy A, Nirantharakumar K, Pang TT, Andrews R, Narendran P. What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review. Diabetologia. 2012; 55(3): 542-51.
11- England LJ, Levine RJ, Qian C, Soule LM, Schisterman EF, Yu KF, Catalano PM. Glucose tolerance and risk of gestational diabetes mellitus in nulliparous women who smoke during pregnancy. American journal of epidemiology. 2004; 160(12): 1205-13.
12- Rani V, Deep G, Singh RK, Palle K, Yadav UC. Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life sciences. 2016; 148:183-93.
13- Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine reviews. 2012; 33(6): 981-1030.
14- Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine. 1995; 2(2): 137-89.
15- McCune LM, Johns T. Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the indigenous peoples of the North American boreal forest. Journal of Ethnopharmacology. 2002; 82(2-3): 197-205.
16- Shapiro K, Gong WC. Natural products used for diabetes. Journal of the American Pharmaceutical Association. 2002; 42(2): 217-26.
17- Ouml; zlem SA, Tuuml; lay AC. Antioxidant, cytotoxic and apoptotic activities of extracts from medicinal plant Euphorbia platyphyllos L. Journal of Medicinal Plants Research. 2013; 7(19): 1293-304.
18- Makheswari U, Sudarsanam D. Phytomedicine for Diabetes mellitus: An overview. Research in Pharmacy. 2015; 1(4): 28-37.
19- Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. Journal of ethnopharmacology. 2002; 81(1): 81-100.
20- Miura T, Itoh C, Iwamoto N, Kato M, Kawai M, Park SR, Suzuki I. Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice. Journal of nutritional science and vitaminology. 2001; 47(5): 340-344.
21- Jarald E, Joshi SB, Jain DC. Diabetes vs herbal medicines. Iranian Journal of Pharmacology and therapeutics. 2008; 7(1): 97-80.
22- Hanhineva K, TÃ¶rrÃ¶nen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, MykkÃ¤nen H, Poutanen K. Impact of dietary polyphenols on carbohydrate metabolism. International journal of molecular sciences. 2010; 11(4): 1365-402.
23- Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM. Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnology advances. 2015; 33(8): 1582-614.
24-Adaramoye OA, Adeyemi EO. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocinâ€induced diabetes mellitus rats. Journal of Pharmacy and Pharmacology. 2006; 58(1):121-8.
25- Rauter AP, Martins A, Borges C, Motaâ€Filipe H, Pinto R, Sepodes B, Justino J. Antihyperglycaemic and protective effects of flavonoids on streptozotocinâ€“induced diabetic rats. Phytotherapy Research. 2010; 24(2): 133-138.
26- Pietta PG. Flavonoids as antioxidants. Journal of natural products. 2000; 63(7):1035-1042.
27- Ngo DN, Kim MM, Kim SK. Chitin oligosaccharides inhibit oxidative stress in live cells. Carbohydrate Polymers. 2008; 74(2): 228-234.
28-Wang X, Xing B. Importance of structural makeup of biopolymers for organic contaminant sorption. Environmental science & technology. 2007; 41(10): 3559-3565.
29-Jayakumar R, Nwe N, Tokura S, Tamura H. Sulfated chitin and chitosan as novel biomaterials. International journal of biological macromolecules. 2007; 40(3): 175-178
30-Rezakhani L, Rashidi Z, Mirzapur P, Khazaei M. Antiproliferatory effects of crab shell extract on breast cancer cell line (MCF7). Journal of breast cancer. 2014; 17(3): 219-25.
31-Yuan WP, Liu B, Liu CH, Wang XJ, Zhang MS, Meng XM, Xia XK. Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats. World Journal of Gastroenterology: WJG. 2009; 15(11): 1339.
32- Kerch G. The potential of chitosan and its derivatives in prevention and treatment of age-related diseases. Marine drugs. 2015; 13(4): 2158-82.
33-Kim JN, Chang IY, Kim HI, Yoon SP. Long-term effects of chitosan oligosaccharide in streptozotocin-induced diabetic rats. Islets. 2009 Sep 1; 1(2):111-116.
34-Ju C, Yue W, Yang Z, Zhang Q, Yang X, Liu Z, Zhang F. Antidiabetic effect and mechanism of chitooligosaccharides. Biological and Pharmaceutical Bulletin. 2010; 33(9): 1511-6.
35-Hashimoto M, Kanda M, Ikeno K, Hayashi Y, Nakamura T, Ogawa Y, Fukumitsu H, Nomoto H, Furukawa S. Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain. Bioscience, biotechnology, and biochemistry. 2005; 69(4):800-5.
36- Khazaei M, Ansarian A, Ghanbari E. New Findings on biological actions and clinical applications of royal jelly: A Review. Journal of dietary supplements. 2017: 1-19.
37-Ghanbari E, Nejati V, Najafi G, Khazaei M, Babaei M. Study on the effect of royal jelly on reproductive parameters in streptozotocin-induced diabetic rats. International journal of fertility & sterility. 2015; 9(1): 113-120.
38- Guo H, Kouzuma Y, Yonekura M. Structures and properties of antioxidative peptides derived from royal jelly protein. Food Chemistry. 2009; 113(1): 238-245.
39- Guo H, Kouzuma Y, Yonekura M. Structures and properties of antioxidative peptides derived from royal jelly protein. Food Chemistry. 2009; 113(1): 238-245.
40- Ahamad J, Amin S, Mir SR. Momordica charantia Linn.(Cucurbitaceae): Review on Phytochemistry and Pharmacology. Phytochemistry. 2017; 11(2):53-65.
41- Coruh N, Celep AS, Ã–zgÃ¶kÃ§e F. Antioxidant properties of Prangos ferulacea (L.) Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on Glutathione-S-transferase. Food chemistry. 2007 Jan 1; 100(3):1237-42.
42- Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine. 1995 Oct 1; 2(2):137-89.
43- Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP. Recent advances in Indian herbal drug research guest editor: Thomas Paul Asir Devasagayam Indian herbs and herbal drugs used for the treatment of diabetes. Journal of clinical biochemistry and nutrition. 2007; 40(3):163-73.
44- Kaneto H, Matsuoka TA, Nakatani Y, Kawamori D, Matsuhisa M, Yamasaki Y. Oxidative stress and the JNK pathway in diabetes. Current diabetes reviews. 2005; 1(1): 65-72.
45- Marles RJ, Kaminski J, Arnason JT, Pazos-Sanou L, Heptinstall S, Fischer NH, Crompton CW, Kindack DG, Awang DV. A bioassay for inhibition of serotonin release from bovine platelets. Journal of natural products. 1992; 55(8): 1044-1056.
46- Afzal Îœ, Al-Hadidi D, Menon M, Pesek J, Dhami MS. Ginger: an ethnomedical, chemical and pharmacological review. Drug metabolism and drug interactions. 2001;18(3-4):159-190.
47-Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. British Journal of Nutrition. 2006; 96(4): 660-666.
48-Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complementary Therapies in Medicine. 2014; 22(1): 9-16.
49- Shanmugam KR, Mallikarjuna K, Kesireddy N, Reddy KS. Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats. Food and chemical toxicology. 2011; 49(4): 893-7.
50-Li Y, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review. Evidence-Based Complementary and Alternative Medicine. 2012; http://dx.doi.org/10.1155/2012/516870.
51- Abdel-Barry JA, Abdel-Hassan IA, Al-Hakiem MH. Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. Journal of ethnopharmacology. 1997; 58(3):149-155.
52- Abraham BK, Adithan C. Review of endocrine pharmacology. Indian journal of Pharmacology 2000; 32: 567-580.
53- Kamboj SS, Chopra K, Sandhir R. Hyperglycemia-induced alterations in synaptosomal membrane fluidity and activity of membrane bound enzymes: beneficial effect of N-acetylcysteine supplementation. Neuroscience. 2009; 162(2): 349-358.
54-Smith M. Therapeutic applications of fenugreek. Alternative Medicine Review. 2003; 8(1): 20-27.
55- Blumenthal M. German Federal Institute for Drugs and Medical Devices. Commission E. Herbal medicine: expanded Commission E monographs. Newton, Mass. Integrative Medicine Communications. 2000: 160-169.
56-Letchamo W, Xu HL, Gosselin A. Variations in photosynthesis and essential oil in thyme. Journal of plant physiology. 1995; 147(1): 29-37.
57- Rana P, Soni G. Antioxidant potential of thyme extract: alleviation of N-nitrosodiethylamine-induced oxidative stress. Human & experimental toxicology. 2008; 27(3): 215-221.
58- Lee SJ, Umano K, Shibamoto T, Lee KG. Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties. Food Chemistry. 2005; 91(1): 131-137.
59- Amin AM, Lotfy M, Shafiullah M, Adeghate E. The protective effect of Tribulus terrestris in diabetes. Annals of the New York Academy of Sciences. 2006; 1084(1):391-401.
60- Li M, Qu W, Chu S, Wang H, Tian C, Tu M. Effect of the decoction of Tribulus terrestris on mice gluconeogenesis. Zhong yao cai= Zhongyaocai= Journal of Chinese Medicinal Materials. 2001; 24(8): 586-588.
61- Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life sciences. 2003; 73(23): 2963-2971.
62- Zhang SJ, Qu WJ, Zhong SY. Inhibitory effects of saponins from Tribulus terrestris on alpha-glucosidase in small intestines of rats. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese Materia Medica. 2006; 31(11):910-3.
63- Posadzki P, Watson LK, Ernst E. Adverse effects of herbal medicines: an overview of systematic reviews. Clinical medicine. 2013; 13(1):7-12.
64- Chander V, Aswal JS, Dobhal R, Uniyal DP. A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata. The Journal of Phytopharmacology. 2017; 6(1):53-58.
65-Fatehi M, Saleh TM, Fatehi-Hassanabad Z, Farrokhfal K, Jafarzadeh M, Davodi S. A pharmacological study on Berberis vulgaris fruit extract. Journal of Ethnopharmacology. 2005; 102(1):46-52.
66- Fallah Huseini H, Fakhrzadeh H, Larijani B, Shikh Samani AH. Review of anti-diabetic medicinal plant used in traditional medicine. Journal of Medicinal Plants. 2006; 1(17):1-8.
67-Erdemoglu N, KÃ¼peli E, YeÅŸilada E. Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. Journal of Ethnopharmacology. 2003; 89(1): 123-129.
68- Cheng CW, Wu TX, Shang HC, Li YP, Altman DG, Moher D, Bian ZX. Consort extension for Chinese herbal medicine formulas 2017: recommendations, explanation, and elaboration. Annals of internal medicine. 2017; 167(2): 112-21.
69- Fukuda T, Ito H, Yoshida T. Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice. Biofactors. 2004; 21(4): 251-253.
70-Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of ethnopharmacology. 2004; 92(1): 1-21.
71- Benelli R, VenÃ¨ R, Bisacchi D, Garbisa S, Albini A. Antiinvasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases. Biol Chem. 2002; 383(1): 101-5.
72- Weisburger JH, Chung FL. Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. Food Chem. Toxicol. 2002; 40(8): 1145-54
73- Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC pharmacology. 2004; 4(1):18.
74-Ryu OH, Lee J, Lee KW, Kim HY, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM. Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients. Diabetes research and clinical practice. 2006; 71(3): 356-8.
75- Li Y, Wang C, Huai Q, Guo F, Liu L, Feng R, Sun C. Effects of tea or tea extract on metabolic profiles in patients with type 2 diabetes mellitus: a meta-analysis of ten randomized controlled trials. Diabetes/Metabolism Research and Reviews. 2016; 32(1):2-10.
76- Moezi L, Arshadi SS, Motazedian T, Seradj SH, Dehghani F. Anti-diabetic effects of amygdalus lycioides spach in streptozocin-induced diabetic rats. Iranian Journal of Pharmaceutical Research: IJPR. 2018; 17(1):353.
77- Babaei H, Sadeghpour O, Nahar L, Delazar A, Nazemiyeh H, Mansouri MR, Poursaeid N, Asnaashari S, Moghadam SB, Sarker SD. Antioxidant and Vasorelaxant Activities of Flavonoids from Amygdalus lycioides var. horrida. Turkish Journal of Biology. 2008; 32(3): 203-208.
78- Sohrab G, Ebrahimof S, Sotoudeh G, Neyestani TR, Angoorani P, Hedayati M, Siasi F. Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial. International journal of food sciences and nutrition. 2017; 68(2): 249-55.
79-Jurenka J. Therapeutic applications of pomegranate (Punica granatum L.): a review. Alternative medicine review. 2008; 13(2):128.
80- Stowe CB. The effects of pomegranate juice consumption on blood pressure and cardiovascular health. Complementary therapies in clinical practice. 2011; 17(2):113-5.
81- Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD, Li Y. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-Î³ and identification of an active component. Toxicology and applied pharmacology. 2005; 207(2):160-169.
82-Li Y, Wen S, Kota BP, Peng G, Li GQ, Yamahara J, Roufogalis BD. Punica granatum flower extract, a potent Î±-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. Journal of Ethnopharmacology. 2005; 99(2): 239-244.
83- Jafri MA, Aslam M, Javed K, Singh S. Effect of Punica granatum Linn.(flowers) on blood glucose level in normal and alloxan-induced diabetic rats. Journal of ethnopharmacology. 2000; 70(3):309-314.
84- Sohrab G, Sotoodeh G, Siasi F, Neiestani T, Rahimi A, Chamari M. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism. 2008; 9(4): 399-405.
85- Afify AM, El-Beltagi HS, Fayed SA, El-Ansary AE. In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats. Grasas y Aceites. 2018; 69(1):243.
86- Eidi A, Eidi M, Darzi R. Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytotherapy Research. 2009; 23(3): 347-50.
87- Jemai H, El Feki A, Sayadi S. Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats. Journal of agricultural and food chemistry. 2009; 57(19): 8798-804.
88- CvjetiÄ‡anin T, MiljkoviÄ‡ D, StojanoviÄ‡ I, Dekanski D, StoÅ¡iÄ‡-GrujiÄiÄ‡ S. Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice. British Journal of Nutrition. 2010; 103(10): 1413-24.
89- Patel SS, Ray RS, Sharma A, Mehta V, Katyal A, Udayabanu M. Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice. Metabolic brain disease. 2018: 1-2.
90- Mehri A, Hasani RS, Larijani B. A systematic review of efficacy and safety of Urtica dioica in the treatment of diabetes. 2011: 161-170.
91- Zargham H, Zargham R. Tannin extracted from Sumac inhibits vascular smooth muscle cell migration. McGill Journal of Medicine: MJM. 2008; 11(2):119.
92- Mavlyanov SM, Islambekov SY, Karimdzhanov AK, Ismaikov AI. Anthocyans and organic acids of the fruits of some species of sumac. Chemistry of Natural Compounds. 1997; 33(2): 279-280.
93- Cai Y, Zhang J, Chen NG, Shi Z, Qiu J, He C, Chen M. Recent advances in anticancer activities and drug delivery systems of tannins. Medicinal research reviews. 2017 Jul 1;37(4):665-701.
94- Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and Î²-cell damage in rat pancreas. Pharmacological research. 2005 Feb 1; 51(2):117-23.
95- Katchan V, David P, Shoenfeld Y. Cannabinoids and autoimmune diseases: A systematic review. Autoimmunity reviews. 2016 Jun 1; 15(6):513-28.
96-Baron EP. Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: What a long strange trip it's beenâ€¦. Headache: The Journal of Head and Face Pain. 2015 Jun 1; 55(6):885-916.
97- Beaulieu P, Ware M. Reassessment of the role of cannabinoids in the management of pain. Curr Opin Anaesthesiol. 2007; 20: 473â€477.
98- Dagon Y, Avraham Y, Link G, Zolotarev O, Mechoulam R, Berry EM. The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells. Neurobiology of disease. 2007; 27(2): 174-181.
99-Lotfi N, Khazaei M, Shariatzadeh SM, Mehranjani MS, Piri F, Ansarian A. Reproductive parameters in diabetic male rat after exposure to cannabis sativa hydroalcoholic extract. Journal of Reports in Pharmaceutical Sciences. 2014; 3(2): 193-200.
100- Croxford JL, Yamamura T. Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? Journal of neuroimmunology. 2005; 166(1): 3-18.
101-Tehranipour M, Mahdavi Shahri N, Ekrami Koushki A, Javad Mousavi BZ. Neuroprotective effects of Cannabis sativa alcoholic extract against spinal alpha motoneurons degeneration in male type II diabetic rats. The Horizon of Medical Sciences. 2012; 18(3):141-147.
102- Chong SK, Oberholzer VG. Ginseng--is there a use in clinical medicine? Postgraduate Medical Journal. 1988; 64(757): 841-846.
103- Ranjbar SH, Larijani B, Abdollahi M. Recent update on animal and human evidences of promising anti-diabetic medicinal plants: a mini-review of targeting new drugs. Asian Journal of Animal and Veterinary Advances. 2011; 6(12): 1271-1275.
104- Tripathi AK, Bhoyar PK, Baheti JR, Biyani DM, Khalique M, Kothmire MS, Amgaonkar YM, Bhanarkar AB. Herbal antidiabetics: A review. Int J Res Pharm Sci. 2011; 2(1):30-
105- Rajasekaran S, Sivagnanam K, Subramanian S. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep. 2005; 57(1): 90-96.
106- Chahardoli M, Mahmoodi M, Hajizadeh MR, Khoramdel Azad H, Khoshdel AR, Mirzaei MR. Effect of Aloe vera hydroalcoholic extract on blood glucose, serum insulin and the key enzymes in metabolic pathways of glycolysis and gluconeogenesis in hepatocytes of type 1 diabetic rats. Journal of Rafsanjan University of Medical Sciences. 2015; 13(8): 669-682.
107- Beppu H, Shimpo K, Chihara T, Kaneko T, Tamai I, Yamaji S, Ozaki S, Kuzuya H, Sonoda S. Antidiabetic effects of dietary administration of Aloe arborescent Miller components on multiple low-dose streptozotocin-induced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components. Journal of ethnopharmacology. 2006; 103(3):468-77.