Diagnostic Accuracy of Modified Alvarado and RIPASA Scores for Acute Appendicitis in Zakho Emergency Hospital: A Cross-Sectional Study

Authors

  • Farhad MR Ahmed Department of Surgery, College of Medicine, University of Zakho, Department of Surgery, Zakho Emergency Teaching Hospital, Zakho, Kurdistan Region, Iraq.
  • Mahmoud Ali Abdi Department of Surgery, College of Medicine, University of Zakho, Zakho, Kurdistan Region, Iraq.
  • Iman Ramadhan Yousif Department of Surgery, College of Medicine, University of Zakho, Zakho, Kurdistan Region, Iraq.
  • Hajar Hassan Abdulqadir Department of Surgery, College of Medicine, University of Zakho, Zakho, Kurdistan Region, Iraq.
  • Yamama Judaan Ali Department of Surgery, College of Medicine, University of Zakho, Zakho, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.22317/jcms.v12i2.2091

Keywords:

Abdominal Pain, Appendicitis, Severity of Illness Index, Clinical Decision Rules, Sensitivity and Specificity, Predictive Value of Tests, Reproducibility of Results

Abstract

Objective: To compare the diagnostic performance of the Modified Alvarado and RIPASA scoring systems in patients presenting with RIF pain.

Methods: A cross-sectional study was conducted at Zakho Emergency Hospital between October 2022 and May 2023. A total of 195 consecutively admitted patients with RIF pain were evaluated using both scoring systems. Histopathology (when available) served as the reference standard. Statistical analysis included descriptive statistics, two-tailed independent t-tests, ANOVA, chi-square tests, logistic regression, and receiver operating characteristic (ROC) curve analysis. Sensitivity, specificity, predictive values, accuracy, and area under the curve (AUC) were calculated with 95% confidence intervals (CI).

Results: Histopathology confirmed appendicitis in 141 patients (72.3%). Using a cutoff ≥7, the MA score showed sensitivity 67.4%, specificity 61.1%, PPV 83.3%, NPV 41.8%, and accuracy 65.6%. The RIPASA score (cutoff ≥10) demonstrated sensitivity 75.9%, PPV 86.3%, NPV 45.8% and accuracy 72.3%, with identical specificity (61.1%). Logistic regression confirmed both scores as significant predictors (p < 0.001). ROC analysis demonstrated acceptable discrimination for both systems.

Conclusion: Both scoring systems demonstrated moderate diagnostic performance. RIPASA showed higher sensitivity and overall discrimination; however, the difference was not statistically significant. These findings suggest that RIPASA may provide incremental diagnostic benefit, but neither score should replace imaging in equivocal cases.

References

Snyder MJ, Guthrie M, Cagle S. Acute appendicitis: efficient diagnosis and management. Am Fam Physician. 2018;98(1):25–33.

Moris D, Paulson EK, Pappas TN. Diagnosis and management of acute appendicitis in adults: a review. JAMA. 2021;326(22):2299–311. doi:10.1001/jama.2021.20502.

Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020;15(1):27. doi:10.1186/s13017-020-00306-3.

Ilves I, Fagerström A, Herzig KH, Juvonen P, Miettinen P, Paajanen H. Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland. World J Gastroenterol. 2014;20(14):4037–4042. doi:10.3748/wjg.v20.i14.4037.

Martín-del Olmo JC, Concejo-Cutoli P, Vaquero-Puerta C, López-Mestanza C, Gómez-López JR. Clinical prediction rules in acute appendicitis: which combination of variables is more effective at predicting? Cir Cir. 2022;90:42–49. doi:10.24875/ciru.21000652

Ahmed SS, Al-Najjar SA. The role of ultrasound in assessing acute right iliac fossa pain. Zanco J Med Sci. 2020;24(1):46–53. doi:10.15218/zjms.2020.007.

Krzyzak M, Mulrooney SM. Acute appendicitis review: background, epidemiology, diagnosis, and treatment. Cureus. 2020;12(6):e8562.

Page D, Hendahewa R. An incarcerated Spigelian hernia with the appendix in the sac passing through all layers of the abdominal wall: an unusual cause for chronic right iliac fossa pain. J Surg Case Rep. 2020;2020(6):rjaa099.

Di Saverio S, Birindelli A, Kelly MD, Catena F, Weber DG, Sartelli M, et al. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016;11:34.

Shogilev DJ, Duus N, Odom SR, Shapiro NI. Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014. West J Emerg Med. 2014;15(7):859–871.

Shuaib A, Shuaib A, Fakhra Z, Marafi B, Alsharaf K, Behbehani A. Evaluation of modified Alvarado scoring system and RIPASA scoring system as diagnostic tools of acute appendicitis. World J Emerg Med. 2017;8(4):276–280.

Arias MP, Barreira AS, Sánchez MM, Eire PF, Saavedra SG, Veiras JG, et al. Appendicitis versus non-specific acute abdominal pain: Paediatric Appendicitis Score evaluation. An Pediatr (Engl Ed). 2018;88(1):32–38.

Benabbas R, Hanna M, Shah J, Sinert R. Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis. Acad Emerg Med. 2017;24(5):523–551.

Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986;15(5):557–564.

Téoule P, de Laffolie J, Rolle U, Reissfelder C. Acute appendicitis in childhood and adulthood: an everyday clinical challenge. Dtsch Arztebl Int. 2020;117(45):764–774.

Pasumarthi V, Madhu CP. A comparative study of RIPASA score and Alvarado score in diagnosis of acute appendicitis. Int Surg J. 2018;5(3):796–801.

Gurav PD, Hombalkar NN, Dhandore P, Hamid M. Evaluation of right iliac fossa pain with reference to Alvarado score: can we prevent unnecessary appendicectomies? JKIMSU. 2013;2(2):24–32.

Frountzas M, Stergios K, Kopsini D, Schizas D, Kontzoglou K, Toutouzas K. Alvarado or RIPASA score for diagnosis of acute appendicitis? A meta-analysis of randomized trials. Int J Surg. 2018;56:307–314.

Díaz-Barrientos CZ, Aquino-González A, Heredia-Montaño M, Navarro-Tovar F, Pineda-Espinosa MA, de Santillana IE. The RIPASA score for the diagnosis of acute appendicitis: a comparison with the modified Alvarado score. Rev Gastroenterol Mex (Engl Ed). 2018;83(2):112–116.

Waseem M, Wang CF. Pediatric appendicitis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jun 17.

Inteti K, Shaik MR, Ganapa P, Gandi PS. A comparison of the Alvarado score and the Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) score in the diagnosis of acute appendicitis: a prospective cohort study. Cureus. 2024;16(8):e68041. doi:10.7759/cureus.68041.

Samir M, Hefzy M, Gaber M, Moghazy K. Added value of graded compression ultrasound to the Alvarado score in cases of right iliac fossa pain. Afr J Emerg Med. 2016;6(3):138–143.

Shaker ZN, Mahdi DS, Alsaimary IE. Demographical study of appendicitis patients in Basra, Iraq. Eur J Med Health Sci. 2024;6(4):1–5.

Yalcinkaya A, Balci B, Keskin C, Erkan I, Yildiz A, Kamer E, et al. Nationwide prospective audit for the evaluation of appendicitis risk prediction models in adults: right iliac fossa treatment (RIFT)—Turkey. BJS Open. 2024;8(5):zrae120.

Benedetto G, Puchol MF, Solaz AL. Suspicion of acute appendicitis in adults: the value of ultrasound in our hospital. Radiologia (Engl Ed). 2019;61(1):51–59.

Heiranizadeh N, Mousavi Beyuki SM, Kargar S, Abadiyan A, Mohammadi HR. Alvarado or RIPASA? Which one do you use to diagnose acute appendicitis? A cross-sectional study. Health Sci Rep. 2023;6(1):e1078.

Abdullah AA, Katoof FM, Jasim HA. RIPASA versus modified Alvarado scoring system in the diagnosis of acute appendicitis, as a new scoring system in Asia. Int J Surg Open. 2018;15:42–45.

Chisthi MM, Surendran A, Narayanan JT. RIPASA and AIR scoring systems are superior to Alvarado scoring in acute appendicitis: diagnostic accuracy study. Ann Med Surg (Lond). 2020;59:138–142.

Chong CF, Adi MI, Thien A, Suyoi A, Mackie AJ, Tin AS, et al. Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis. Singapore Med J. 2010;51(3):220–225.

Cohen JF, Korevaar DA, Altman DG, Bruns DE, Gatsonis CA, Hooft L, Irwig L, Levine D, Reitsma JB, De Vet HC, Bossuyt PM. STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration. BMJ open. 2016 Nov 1;6(11):e012799. https://doi.org/10.1136/bmjopen-2016-012799

Downloads

Published

2026-04-26

How to Cite

Ahmed, F. M., Ali Abdi, M., Yousif, I. R., Abdulqadir, H. H., & Yamama Judaan Ali. (2026). Diagnostic Accuracy of Modified Alvarado and RIPASA Scores for Acute Appendicitis in Zakho Emergency Hospital: A Cross-Sectional Study. Journal of Contemporary Medical Sciences, 12(2), 76–81. https://doi.org/10.22317/jcms.v12i2.2091