Trends in Head and Neck Cancer in Saudi Arabia from 2016–2020
DOI:
https://doi.org/10.22317/jcms.v11i2.1664Keywords:
Head and neck cancer, Cancer incidence, Saudi cancer registry, Age-standardised rate, age-specific incidence rateAbstract
Objectives: Head and neck cancer (HNC) is considered the seventh most common cancer worldwide. To evaluate the incidence and geographical distributions of head and neck cancer among the Saudi population in a specific period.
Methods: A retrospective and a descriptive study investigating HNC in Saudi population from January 2016 through December 2020 was conducted based on data obtained from the Saudi Cancer Registry SCR. Male and female data were included on lip, tongue, mouth salivary glands, oropharynx, nasopharynx hypopharynx, pharynx, nose and sinuses, and larynx. Age-standardized rate (ASR) and age-specific incidence rate (AIR) were calculated with a focus on age, gender and regional differences.
Results: The total number of HNC cases identified by the SCR was 3,232 cases in which males were 2082 (64.4%) and females were 1,150 (35.5%). The mean ASR per 100,000 of HNC was higher in males at 4.94 compared to females at 2.9 over the study period. The mean ASR per 100,000 population ranged from 2.22 in Hail to 5.3 in Jazan, with a national average of 3.68 per 100,000. Positive correlation between HNC incidence and age was noted. Nasopharyngeal cancer showed the highest number of cases for both genders through the same period.
Conclusion: Between 2016 and 2020, HNC incidence in Saudi Arabia remained stable, with consistently higher ASR in males. These findings highlight the importance of targeted, region-specific health initiatives, greater public education, and age-targeted screening to reduce the impact of HNC in Saudi Arabia.
References
Abdullah Dakheel Alotaibi a, H. G. A. a., Abdelbaset Mohamed Elasbali (2019). Nasopharyngeal cancer in Saudi Arabia: Epidemiology and possible risk factors. Journal of Oncological Science, 5(1), 23-30. https://doi.org/10.1016/j.jons.2019.01.002
Albar, M. A. (1994). Islamic teachings and cancer prevention. J Family Community Med, 1(1), 79-86. https://www.ncbi.nlm.nih.gov/pubmed/23008539
Alharbi, F. (2017). Incidence of Head and Neck Cancers in Jazan Province, Saudi Arabia. Saudi Journal of oto-Rhino-laryngology head and neck surgery, 9(2). https://doi.org/10.4103/1319-8491.275315
Aljanobi, H. (2022). Prevalence of Head and Neck Cancer in the Eastern Provence of Saudi Arabia- Cross Sectional Analysis. Heliyon. https://doi.org/10.2139/ssrn.4173724
Alsanosy, R. M., Mahfouz, M. S., & Gaffar, A. M. (2013a). Khat chewing among students of higher education in Jazan region, Saudi Arabia: prevalence, pattern, and related factors. Biomed Res Int, 2013, 487232. https://doi.org/10.1155/2013/487232
Alsanosy, R. M., Mahfouz, M. S., & Gaffar, A. M. (2013b). Khat chewing habit among school students of Jazan region, Saudi Arabia. PLoS One, 8(6), e65504. https://doi.org/10.1371/journal.pone.0065504
Alsharif, A., Alsharif, M. T., Samman, M., Binmadi, N., Kassim, S., Mourad, S., & Warnakulasuriya, S. (2023). Forecasting Head and Neck Cancer Trends in GCC Countries: Implications for Public Health Policy and Strategy. Risk Manag Healthc Policy, 16, 2943-2952. https://doi.org/10.2147/RMHP.S445162
Alshehri, B. M. (2020). Trends in the incidence of oral cancer in Saudi Arabia from 1994 to 2015. World J Surg Oncol, 18(1), 217. https://doi.org/10.1186/s12957-020-01989-3
Alzahrani, R. (2020). Epidemiological Study of Head and Neck Cancer in Al-Baha- region, South West of Saudi Arabia [original research]. Journal of Otolaryngology and RhinologY, 6(2). https://doi.org/10.23937/2572-4193.1510085
Asiri, S. S. O., Dalia Abdullah; Alhamlan, Fatimah Saeed. (2020). Human Papillomavirus Associated with Head and Neck Cancer in the Middle East and North Africa A Systematic Review and Meta-Analysis
[ORIGINAL ARTICLE]. Journal of Nature and Science of Medicine, 3(3), 170-181. https://doi.org/10.4103/JNSM.JNSM_70_19
Bazarbashi, S., Al Eid, H., & Minguet, J. (2017). Cancer Incidence in Saudi Arabia: 2012 Data from the Saudi Cancer Registry. Asian Pac J Cancer Prev, 18(9), 2437-2444. https://doi.org/10.22034/APJCP.2017.18.9.2437
Brown, A., Ravichandran, K., & Warnakulasuriya, S. (2006). The unequal burden related to the risk of oral cancer in the different regions of the Kingdom of Saudi Arabia. Community Dent Health, 23(2), 101-106. https://www.ncbi.nlm.nih.gov/pubmed/16800366
Chow, L. Q. M. (2020). Head and Neck Cancer. N Engl J Med, 382(1), 60-72. https://doi.org/10.1056/NEJMra1715715
Gaffar, A. M., Alsanosy, R. M., & Mahfouz, M. S. (2013). Sociodemographic factors associated with tobacco smoking among intermediate and secondary school students in Jazan Region of Saudi Arabia. Subst Abus, 34(4), 381-388. https://doi.org/10.1080/08897077.2013.779361
Galbiatti, A. L., Padovani-Junior, J. A., Maniglia, J. V., Rodrigues, C. D., Pavarino, E. C., & Goloni-Bertollo, E. M. (2013). Head and neck cancer: causes, prevention and treatment. Braz J Otorhinolaryngol, 79(2), 239-247. https://doi.org/10.5935/1808-8694.20130041
Gillison, M. L., Chaturvedi, A. K., Anderson, W. F., & Fakhry, C. (2015). Epidemiology of Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma. J Clin Oncol, 33(29), 3235-3242. https://doi.org/10.1200/JCO.2015.61.6995
Gormley, M., Creaney, G., Schache, A., Ingarfield, K., & Conway, D. I. (2022). Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. Br Dent J, 233(9), 780-786. https://doi.org/10.1038/s41415-022-5166-x
Gupta, S., Gupta, R., Sinha, D. N., & Mehrotra, R. (2018). Relationship between type of smokeless tobacco & risk of cancer: A systematic review. Indian J Med Res, 148(1), 56-76. https://doi.org/10.4103/ijmr.IJMR_2023_17
Hobbs, C. G., Sterne, J. A., Bailey, M., Heyderman, R. S., Birchall, M. A., & Thomas, S. J. (2006). Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol, 31(4), 259-266. https://doi.org/10.1111/j.1749-4486.2006.01246.x
Johnson, D. E., Burtness, B., Leemans, C. R., Lui, V. W. Y., Bauman, J. E., & Grandis, J. R. (2020). Head and neck squamous cell carcinoma. Nat Rev Dis Primers, 6(1), 92. https://doi.org/10.1038/s41572-020-00224-3
Kabli, A. F., Miyajan, K. F., Alqurashi, A. S., Mandili, A. K., Mujahed, R. M., Hafiz, B. F., Mandora, R. M., & Herabi, A. Z. (2022). Trends in the Incidence of Nasopharyngeal Cancer in Saudi Arabia Across One Decade (2007 to 2016). Cureus, 14(5), e24732. https://doi.org/10.7759/cureus.24732
Louie, K. S., Mehanna, H., & Sasieni, P. (2015). Trends in head and neck cancers in England from 1995 to 2011 and projections up to 2025. Oral Oncol, 51(4), 341-348. https://doi.org/10.1016/j.oraloncology.2015.01.002
Mahfouz, M. S., Alsanosy, R. M., & Gaffar, A. M. (2013). The role of family background on adolescent khat chewing behavior in Jazan Region. Ann Gen Psychiatry, 12(1), 16. https://doi.org/10.1186/1744-859X-12-16
Miranda-Filho, A., & Bray, F. (2020). Global patterns and trends in cancers of the lip, tongue and mouth. Oral Oncol, 102, 104551. https://doi.org/10.1016/j.oraloncology.2019.104551
Quadri, M. F., Alharbi, F., Bajonaid, A. M., Moafa, I. H., Sharwani, A. A., & Alamir, A. H. (2015). Oral squamous cell carcinoma and associated risk factors in Jazan, Saudi Arabia: a hospital based case control study. Asian Pac J Cancer Prev, 16(10), 4335-4338. https://doi.org/10.7314/apjcp.2015.16.10.4335
Service, N. H. (28 October 2021, 28 October 2021). Head and neck cancer. Retrieved 13 August 2024 from https://www.nhs.uk/conditions/head-and-neck-cancer/
Sheikh, K. A., El-Setouhy, M., Yagoub, U., Alsanosy, R., & Ahmed, Z. (2014). Khat chewing and health related quality of life: cross-sectional study in Jazan region, Kingdom of Saudi Arabia. Health Qual Life Outcomes, 12, 44. https://doi.org/10.1186/1477-7525-12-44
Shield, K. D., Ferlay, J., Jemal, A., Sankaranarayanan, R., Chaturvedi, A. K., Bray, F., & Soerjomataram, I. (2017). The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin, 67(1), 51-64. https://doi.org/10.3322/caac.21384
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 71(3), 209-249. https://doi.org/10.3322/caac.21660
Warnakulasuriya, S. (2009). Global epidemiology of oral and oropharyngeal cancer. Oral Oncol, 45(4-5), 309-316. https://doi.org/10.1016/j.oraloncology.2008.06.002
Zhu, Y., Song, X., Li, R., Quan, H., & Yan, L. (2019). Assessment of Nasopharyngeal Cancer in Young Patients Aged = 30 Years. Front Oncol, 9, 1179. https://doi.org/10.3389/fonc.2019.01179
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