Prothrombin G20210A Mutation in Sudanese Women with Recurrent Pregnancy Loss

Authors

  • Awad Elkareem Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
  • Salaheldein G. Alzaki Federal Ministry of Health, Tropical Medicine Research Institute, Khartoum, Sudan.
  • Mubark A. Mohammed Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Abdalrahman A. Ibrahim Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Amel N. Eltayeb Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Alaa K. Abdellatief Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Anna A. Mustafa Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Matab A. Elsayed Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Esraa H. Osman Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
  • Enas Y. Haj Taha Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.

DOI:

https://doi.org/10.22317/jcms.v10i2.1529

Keywords:

Pregnancy loss; Prothrombin; G20210A; mutation

Abstract

The association between the Prothrombin G20210A mutation and recurrent pregnancy loss is well documented in the literature among different populations. A descriptive study was conducted in Omdurman Maternity Hospital, Sudan, to find the prevalence of the Prothrombin G20210A mutation among Sudanese women with recurrent pregnancy loss. Analysis of the Prothrombin G20210A mutation was performed using PCR-RFLP for  67 enrolled women with recurrent pregnancy loss of two times or more. Data analysis was performed using SPSS. The prothrombin G20210A mutation was present in 4 (6%) out of the total 67 enrolled cases; 3 (4.5%) had the GA genotype (hetrozygous), while one had the (1.5%) AA genotype. The study revealed that the Prothrombin G20210A mutation is less prevalent among Sudanese women with recurrent pregnancy loss compared to other Arab nations. A large case-control study is needed.

References

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Published

2024-04-30

How to Cite

Awad Elkareem, Alzaki, S. G. ., Mohammed, M. A. ., Ibrahim, A. A. ., Eltayeb, A. N. ., Abdellatief, A. K. ., Mustafa, A. A. ., Elsayed, M. A. ., Osman, E. H. ., & Haj Taha, E. Y. . (2024). Prothrombin G20210A Mutation in Sudanese Women with Recurrent Pregnancy Loss. Journal of Contemporary Medical Sciences, 10(2). https://doi.org/10.22317/jcms.v10i2.1529

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Section

Short Communication