Mentha Piperita and Thymus Vulgaris Ameliorate Hematological Changes Induced by Chronic Consumption of Oxidized Palm Oil in Rats


  • Hadeil Muhanna Alsufiani Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Experimental Biochemistry Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Mashael Arif Alsharari Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Chemistry Department, Faculty of Science, Jouf University, Sakaka, Saudi Arabia.
  • Rasha A. Mansouri Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Nadia Nour Osman Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Food Irradiation Research Department., National Centre for Radiation Research and Technology (NCRRT), Cairo, Egypt.



Oxidized palm oil; Mentha piperita; Thymus vulgaris; Hematological indices; Antioxidant


Objective: The aim of this study was to investigate the effect of Mentha piperita L and/or Thymus vulgaris in ameliorating the hematological changes induced by chronic consumption of oxidized palm oil (OPO) in rats.

Methodology: Fifty rats were divided into five groups as follows: rats received a basal diet (control), rats received a basal diet sustained with OPO, rats fed OPO and received Mentha piperita extract, rats fed OPO and received Thymus vulgaris extract, and finally rats fed OPO and received both extracts. After 6 weeks, blood samples were withdrawn and a complete blood count test was done.

Results: Rats fed a diet containing OPO showed a significant decrease in red blood cells (RBCs), hematocrit (Hct), mean corpuscular volume (MCV), hemoglobin (Hb), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), lymphocytes (LYM), and platelets (PLTs) accompanied by a significant increase in white blood cells (WBCs), red cell distribution width (RDW), and mean platelet volume (MPV) compared to rats fed a normal diet. In contrast, rats fed on diet containing OPO and the aqueous extract of either Mentha piperita or Thymus vulgaris showed a significant increase in RBCs, Hct, MCV, Hb, MCH, MCHC, LYM, and PLTs accompanied by a significant decrease in RDW, WBCs, and MPV relative to rats fed on diet containing OPO only. Treatment with a combination of both plants showed better improvements.

Conclusion: Both Mentha piperita and Thymus vulgaris ameliorate the hematological changes induced by OPO.


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How to Cite

Alsufiani, H. M., Alsharari, M. A., Mansouri, R. A., & Osman, N. N. (2024). Mentha Piperita and Thymus Vulgaris Ameliorate Hematological Changes Induced by Chronic Consumption of Oxidized Palm Oil in Rats. Journal of Contemporary Medical Sciences, 10(2).