Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.

  • Fatemeh Ahmadi Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
  • Saeed Hajihashemi Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran. http://orcid.org/0000-0003-3854-3089
  • Ali Rahbari Department of Pathology, Arak University of Medical Sciences, Arak, Iran.
  • Fatemeh Ghanbari Department of Pharmacology, Islamic Azad University, Arak Branch, Arak, Iran.

Abstract

Objective: Renal ischemia-reperfusion (I-R) induces acute kidney injury (AKI). In this study, the effect of hydralazine was investigated on the renal injury induced by the I-R in rats.
Methods: AKI was induced with bilateral obstruction of the renal artery and vein for 20 minutes following with 24 hours of reperfusion. Hydralazine (5mg/kg) was injected intraperitoneally as post- treatment.
Results: Hydralazine significantly increased the levels of renal clearance of creatinine and renal blood flow, while was decreasing by I-R. Also, hydralazine significantly improved levels of serum electrolytes (sodium and potassium) that were impaired by I-R. The tissue MDA levels were significantly suppressed by hydralazine.
Conclusion: According to the results, the post treatment of hydralazine had a therapeutic effect on renal ischemia-reperfusion because improved ion reabsorption and excretion and increased renal blood flow and glomerular filtration rate and decreased lipid peroxidation.
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Published
2019-12-31
How to Cite
AHMADI, Fatemeh et al. Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.. Journal of Contemporary Medical Sciences, [S.l.], v. 5, n. 6, dec. 2019. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/622>. Date accessed: 09 apr. 2020.