Comparison between Gingival Pyogenic Granuloma and Peripheral Giant Cell Granuloma by Immunohistochemical Detection of CD34 and Alpha Smooth Muscle Actin
AbstractObjectives: The aim of the present research was to study the clinical and the immunohistochemical expressions of CD34 and alpha smooth muscle actin (α-SMA) for gingival pyogenic granuloma in comparison with peripheral giant cell granuloma.
Methods: Formalin fixed, paraffin-embedded biopsy specimens of (48) gingival pyogenic granuloma and (39) peripheral giant cell granuloma were used in the study. Immunohistochemical analysis for CD34 and α-SMA were studied in PG and PGCG.
Results: The mean numbers of the CD34 positive micro vessels in PGs and PGCGs were 32.58± 17.778 and 22.4±11.208 respectively. Statistical analysis showed a highly significant difference present between them (P<0.01).The mean numbers of blood vessels with vascular surrounding cells non-reactive to α-SMA in PGs and PGCGs were 3.81± 2.228 and 10.53±3.432 respectively. Statistical analysis showed a highly significant differences present between them (p<0.01).
Conclusion: The mean number of CD34 positive micro vessels in PGs was significantly more than that of PGCG, but the mean number of vascular surrounding cells non-reactive to α-SMA was significantly less. This can add insight to the clinical behavior and might reflect the differences in pathogenesis of these lesions.
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