Comparison between Gingival Pyogenic Granuloma and Peripheral Giant Cell Granuloma by Immunohistochemical Detection of CD34 and Alpha Smooth Muscle Actin

  • Aween Auda Ablahad Ministry of Health, Erbil, Kurdistan Region, Iraq.
  • Ameera Kamal Khleel Department of Dentistry, Al-Hussein University College, Karbala, Iraq.
  • Jasim Almahana Department of Dentistry, Al-Hussein University College, Karbala, Iraq.

Abstract

Objectives: The aim of the present research was to study the clinical and the immunohistochemical expressions of CD34 and alpha smooth muscle actin (α-SMA) for gingival pyogenic granuloma in comparison with peripheral giant cell granuloma. 
 
Methods: Formalin fixed, paraffin-embedded biopsy specimens of (48) gingival pyogenic granuloma and (39) peripheral giant cell granuloma were used in the study. Immunohistochemical analysis for CD34 and α-SMA were studied in PG and PGCG.
 
Results: The mean numbers of the CD34 positive micro vessels in PGs and PGCGs were 32.58± 17.778 and 22.4±11.208 respectively. Statistical analysis showed a highly significant difference present between them (P<0.01).The mean numbers of blood vessels with vascular surrounding cells non-reactive to α-SMA in PGs and PGCGs were 3.81± 2.228 and 10.53±3.432 respectively.  Statistical analysis showed a highly significant differences present between them (p<0.01).
Conclusion: The mean number of CD34 positive micro vessels in PGs was significantly more than that of PGCG, but the mean number of  vascular surrounding cells non-reactive to α-SMA  was significantly less. This can add insight to the clinical behavior and might reflect the differences in pathogenesis of these lesions.
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Published
2019-06-28
How to Cite
ABLAHAD, Aween Auda; KHLEEL, Ameera Kamal; ALMAHANA, Jasim. Comparison between Gingival Pyogenic Granuloma and Peripheral Giant Cell Granuloma by Immunohistochemical Detection of CD34 and Alpha Smooth Muscle Actin. Journal of Contemporary Medical Sciences, [S.l.], v. 5, n. 3, june 2019. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/611>. Date accessed: 21 nov. 2019.
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Articles