Predictive factors of survival rate in oral squamous cell carcinoma: A retrospective study in Iran

  • Narges Gholizadeh Oral & Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.
  • Hanieh Emami Razavi Department of Research Center of Tehran University of Medical Science, Tehran, Iran.
  • Gholamali Jafari Haftkhani Department of Ear, Nose, Throat and Head and Neck surgery, Baqiyatallah University of Medical Science, Tehran, Iran.
  • Nafiseh Sheykhbahaei Oral & Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran, Iran.


Objective: Oral cancer as a part of this collection plays an important role in the burden of diseases, especially in South Asia. Despite numerous advances in the treatment of cancers, oral cancer is one of the top ten causes of death due to delayed detection. Given the role of the environmental and climatic conditions in cancers, there is a need for epidemiological studies in different geographic areas.
Methods: In present study, data were collected through medical records of the patients with oral cancer during 2009 to 2012 in the archives of the Cancer Department of the Ministry of Health of the Islamic Republic of Iran. The follow-up of 82 cases was possible in the study. Data collection were performed from questionnaire. The data were analyzed by SPSS version 20. The Kaplan Meier survival curves were utilized and, moreover, the corresponding influential factors were examined by using the Cox regression test.
Result: The overall five-year survival rate was 40.24% (SE= 5.5). The most widely used treatment method was a combination of three methods of surgery, radiation therapy, and chemotherapy. The gender of 64.63%of patients were male. The mean age of patients were 66.1 years. The age and regular periodic follow-up had a statistically significant relation with the survival rate (P=0.02, P=0.03).
Conclusion: Oral cancers require special attention due to high prevalence and overall survival rates. Training oral health care providers, and periodic follow up can be an important step in increasing the survival of these patients.
share this Article by


1 Yasmin Bhurgri, 'Cancer of the Oral Cavity-Trends in Karachi South (1995-2002)', Asian Pac J Cancer Prev, 6 (2005), 22-6.
2 Boudewijn JM Braakhuis, C René Leemans, and Otto Visser, 'Incidence and Survival Trends of Head and Neck Squamous Cell Carcinoma in the Netherlands between 1989 and 2011', Oral oncology, 50 (2014), 670-75.
3 Daniel Brandizzi, Jorge A Chuchurru, HE Lanfranchi, and Rómulo Luis Cabrini, 'Analysis of the Epidemiological Features of Oral Cancer in the City of Buenos Aires', (2005).
4 Xavier DR Brouha, Debbie M Tromp, Gert‐Jan Hordijk, Jacques AM Winnubst, and J Rob J de Leeuw, 'Oral and Pharyngeal Cancer: Analysis of Patient Delay at Different Tumor Stages', Head & Neck: Journal for the Sciences and Specialties of the Head and Neck, 27 (2005), 939-45.
5 Arun Chandu, G Adams, and Andrew CH Smith, 'Factors Affecting Survival in Patients with Oral Cancer: An Australian Perspective', International journal of oral and maxillofacial surgery, 34 (2005), 514-20.
6 YK Chen, HC Huang, LM Lin, and CC Lin, 'Primary Oral Squamous Cell Carcinoma: An Analysis of 703 Cases in Southern Taiwan', Oral oncology, 35 (1999), 173-79.
7 P Dios Diz, N González Padrón, J Lestón Seoane, I Carmona Tomás, J Posse Limeres, and P Varela-Centelles, '" Scheduling Delay" in Oral Cancer Diagnosis: A New Protagonist', Oral oncology, 41 (2005), 142-46.
8 Hamideh Ehtesham, Reza Safdari, Arash Mansourian, Shahram Tahmasebian, Niloofar Mohammadzadeh, Marjan Ghazisaeedi, and Azadeh Bashiri, 'Clinical Decision Support System, a Potential Solution for Diagnostic Accuracy Improvement in Oral Squamous Cell Carcinoma: A Systematic Review', Journal of Oral Health and Oral Epidemiology, 6 (2017), 187-95.
9 Yi Fan, Lei Zheng, Ming-Hui Mao, Ming-Wei Huang, Shu-Ming Liu, Jie Zhang, Sheng-Lin Li, Lei Zheng, and Jian-Guo Zhang, 'Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients', Asian Pac J Cancer Prev, 15 (2014), 8887-91.
10 Qi-Gen Fang, Shuang Shi, Fa-Yu Liu, and Chang-Fu Sun, 'Squamous Cell Carcinoma of the Oral Cavity in Ever Smokers: A Matched-Pair Analysis of Survival', Journal of Craniofacial Surgery, 25 (2014), 934-37.
11 RE Gehani, and SHL Goteti, 'Squamous Cell Carcinoma of Oral Cavity: Changing Trends', J Dent Health Oral Disord Ther, 2 (2015), 00051.
12 Narges Gholizadeh, Shamsolmoulouk Najafi, Mina Khayam Zadeh, Sajad Afzali, and Nafiseh Sheykhbahaei, 'Trend in Laryngeal Cancer, Mortality and Survival Rate in Iran', Journal of Contemporary Medical Sciences, 4 (2018).
13 Neha Gupta, Ritu Gupta, Arun Kumar Acharya, Basavaraj Patthi, Venkatesh Goud, Somanath Reddy, Anshul Garg, and Ashish Singla, 'Changing Trends in Oral Cancer-a Global Scenario', Nepal journal of epidemiology, 6 (2016), 613.
14 João Adolfo Costa Hanemann, Denise Tostes Oliveira, Suely Nonogaki, Inês Nobuko Nishimoto, Marina Lara de Carli, Gilles Landman, and Luiz Paulo Kowalski, 'Expression of E-Cadherin and Β-Catenin in Basaloid and Conventional Squamous Cell Carcinoma of the Oral Cavity: Are Potential Prognostic Markers?', BMC cancer, 14 (2014), 395.
15 Takumi Hasegawa, Souichi Yanamoto, Mitsunobu Otsuru, Shin-ichi Yamada, Tsutomu Minamikawa, Takashi Shigeta, Tomofumi Naruse, Takatsugu Suzuki, Masashi Sasaki, and Yoshihide Ota, 'Retrospective Study of Treatment Outcomes after Postoperative Chemoradiotherapy in Japanese Oral Squamous Cell Carcinoma Patients with Risk Factors of Recurrence', Oral surgery, oral medicine, oral pathology and oral radiology, 123 (2017), 524-30.
16 Juan C Hernández-Guerrero, Luís F Jacinto-Alemán, María D Jiménez-Farfán, Alejandro Macario-Hernández, Florentino Hernández-Flores, and Avissai Alcántara-Vázquez, 'Prevalence Trends of Oral Squamous Cell Carcinoma. Mexico City’s General Hospital Experience', Medicina oral, patologia oral y cirugia bucal, 18 (2013), e306.
17 Jeong Seok Hwa, Oh Jin Kwon, Jung Je Park, Seung Hoon Woo, Jin Pyeong Kim, Gyung Hyuck Ko, Ji Hyun Seo, and Rock Bum Kim, 'The Prognostic Value of Immunohistochemical Markers for Oral Tongue Squamous Cell Carcinoma', European Archives of Oto-Rhino-Laryngology, 272 (2015), 2953-59.
18 Ahmad Jafari, Narges Gholizadeh, Rashid Ramezani, Hanie Emami Razavi, and Shamsolmoulouk Najafi, 'Evaluation of Survival Rate in Patients with Laryngeal Cancer', Journal of Dental Medicine, 30 (2017), 89-96.
19 D Kerdpon, and H Sriplung, 'Factors Related to Delay in Diagnosis of Oral Squamous Cell Carcinoma in Southern Thailand', Oral oncology, 37 (2001), 127-31.
20 Carlo La Vecchia, Franca Lucchini, Eva Negri, and Fabio Levi, 'Trends in Oral Cancer Mortality in Europe', Oral oncology, 40 (2004), 433-39.
21 Joshua E Muscat, John P Richie, Seth Thompson, and Ernst L Wynder, 'Gender Differences in Smoking and Risk for Oral Cancer', Cancer research, 56 (1996), 5192-97.
22 M Perera, NN Al-Hebshi, I Perera, D Ipe, GC Ulett, DJ Speicher, T Chen, and NW Johnson, 'Inflammatory Bacteriome and Oral Squamous Cell Carcinoma', Journal of dental research, 97 (2018), 725-32.
23 Varsha Salian, Chethana Dinakar, Pushparaja Shetty, and Vidya Ajila, 'Etiological Trends in Oral Squamous Cell Carcinoma: A Retrospective Institutional Study', Cancer Translational Medicine, 2 (2016), 33.
24 Katayoun Sargeran, 'Oral Cancer in Tehran, Iran: An Approach for Understanding Disease Burden', (2008).
25 Katayoun Sargeran, Heikki Murtomaa, Seyed Mohammad Reza Safavi, Miira M Vehkalahti, and Olli Teronen, 'Survival after Diagnosis of Cancer of the Oral Cavity', British Journal of Oral and Maxillofacial Surgery, 46 (2008), 187-91.
26 Sol Silverman, A Ross Kerr, and Joel B Epstein, 'Oral and Pharyngeal Cancer Control and Early Detection', Journal of Cancer Education, 25 (2010), 279-81.
27 Patravoot Vatanasapt, Krittika Suwanrungruang, Supot Kamsa-Ard, Supannee Promthet, and MD Parkin, 'Epidemiology of Oral and Pharyngeal Cancers in Khon Kaen, Thailand: A High Incidence in Females', Asian Pac J Cancer Prev, 12 (2011), 2505-08.
28 Saman Warnakulasuriya, 'Living with Oral Cancer: Epidemiology with Particular Reference to Prevalence and Life-Style Changes That Influence Survival', Oral oncology, 46 (2010), 407-10.
How to Cite
GHOLIZADEH, Narges et al. Predictive factors of survival rate in oral squamous cell carcinoma: A retrospective study in Iran. Journal of Contemporary Medical Sciences, [S.l.], v. 5, n. 2, apr. 2019. ISSN 2413-0516. Available at: <>. Date accessed: 16 june 2019.