TY - JOUR AU - Jahandideh, Ali Akbar AU - Rohani, Hadi AU - Rajabi, Hamid AU - Shariatzadeh, Mohammad AU - Razmjou, Sahar PY - 2021/04/26 Y2 - 2024/03/29 TI - LEP and LEPR Polymorphisms Influences Anthropometric Outcome in Response to 8 Weeks of Combined Training in Obese boys JF - Journal of Contemporary Medical Sciences JA - J. Contemp. Med. Sci. VL - 7 IS - 2 SE - Articles DO - 10.22317/jcms.v7i2.928 UR - https://www.jocms.org/index.php/jcms/article/view/928 SP - 96-101 AB - <p><em>Objectives:</em>&nbsp; The purpose of the present study was to investigate whether <em>LEP19 G&gt;A</em> and <em>LEPR 668 A&gt;G</em> polymorphisms, would influence the effect of an 8-week combined aerobic and resistance training.</p><p><em>Methods:</em> Thirty obese boys (BMIz&gt;+2) aged 11-13 (12.66±0.47) were recruited from three middle schools in Quchan. The changes in body composition parameters and metabolic factors in response to 8-weeks combined aerobic and resistance training program were analyzed regarding <em>LEP</em> and <em>LEPR</em> polymorphism. DNA was extracted from cheek cells donated by the 30 participants and genotyping was carried out using PCR.</p><p><em>Results:</em> Our results suggest that carriers of <em>rs2167270G</em> allele and rs1137101A allele were characterized by a greater reduction in body mass and WHR (P&lt; 0.05). Also, a significant decrease was observed in leptin levels in carriers of <em>rs2167270G</em> allele after the training program (P=0.031). Moreover, the LEP and LEPR polymorphisms were associated with changes in lipid profile in response to training.</p><p><em>Conclusion:</em> In response to 8 weeks of regular physical activity, obese boys with G (<em>rs2167270</em>) and A (<em>rs1137101</em>) alleles had the best likelihood of losing weight which was associated with a decrease in body mass, fat mass (%), WHR and leptin concentrations.</p> ER -