TY - JOUR AU - Al-Wazni, Wafaa Sadeq AU - Hadi, Bashair Sami PY - 2016/01/08 Y2 - 2024/03/28 TI - Antivirulence effects of pomegranate peel extracts on most common urinary tract infection pathogens in pregnant women JF - Journal of Contemporary Medical Sciences JA - J. Contemp. Med. Sci. VL - 1 IS - 4 SE - Articles DO - 10.22317/jcms.v1i4.45 UR - https://www.jocms.org/index.php/jcms/article/view/45 SP - 7-12 AB - <p>Objective This study includes the investigation of antibacterial and antivirulence activities of three types of pomegranate peel extracts and<br />then determines the interaction between the extracts and antibiotic in vitro.<br />Methods The ability of most common isolated bacteria from urinary tract infection (UTI) to produce different virulence factors were tested<br />and the effect of plant extracts on virulence factors were determined; in addition the correlation between extracts and antibiotics were<br />evaluated by using fractional inhibitory concentrations.<br />Results The inhibition zones diameters of the pomegranate peel extracts against most common isolated bacteria (Staphylococcus aureus and<br />Escherichia coli) increase significantly with increase in concentrations. There is no effect of the extracts on the ability of studied bacteria to<br />produce hemolysin and protease enzymes, while both studied bacteria lost its ability to produce β-lactamase enzyme after treating with MIC.<br />In addition, extracts were affected largely on adherence activity and biofilm forming ability of tested bacteria. The results found that the<br />pomegranate peel extracts effect alone against pathogenic bacteria was good than they interacted with antibiotics, in most of the results.<br />Conclusion The alcohol extract was the best solvent in its effects on bacterial pathogen and its effect was largely on the ability of the studied<br />bacteria to form biofilm and adhesion on the epithelial cell. The pomegranate peel extracts were high synergism with some antibiotics<br />against pathogenic bacteria.</p> ER -