@article{S.Hariri_Shayesteh_Asgharian_Chamanara_Sadrzadeh-Afshar_2021, title={Eremostachys Binalodensis, A Potential Therapeutic Choice for Gingival Inflammatory Wounds}, volume={7}, url={https://www.jocms.org/index.php/jcms/article/view/976}, DOI={10.22317/jcms.v7i3.976}, abstractNote={<p><strong>Objectives: </strong>In this study we aimed to evaluate the effect of <em>E. binalodensis</em> on gingival inflammatory wounds.</p> <p><strong>Methods: </strong>In-vitro wound was induced by scratching the surface layer of human gingival fibroblasts (hGFs). Cells were pretreated with 1,10,100,1000 µg/ml of E. binalodensis methanol extract prior to 1µg/ml LPS stimulation. hGFs proliferation was assessed by MTT test. Also levels of critical inflammatory cytokines such as IL-1𝛽, IL-6 and TNF-𝛼 were determined by enzyme-linked immunosorbent assay (ELISA).</p> <p><strong>Results:</strong> Wound induction was associated with secretion of IL-1β, IL-6 and TNF-α from hGFs. <em>E. binalodensis</em> enhanced the hGFs proliferation besides reducing the level of IL-1β, IL-6 and TNF-α in LPS-scratch-stimulated hGFs.</p> <p><strong>Conclusions:</strong> Regarding anti-inflammatory and proliferative effects of E. binalodensis on hGFs, availability and safety of it, it is suggested for enhancing the wound healing process in gingival inflammatory wounds.</p>}, number={3}, journal={Journal of Contemporary Medical Sciences}, author={S.Hariri, Armin and Shayesteh, Sevda and Asgharian, Parina and Chamanara, Mohsen and Sadrzadeh-Afshar, Maryam-Sadat}, year={2021}, month={Jun.}, pages={140–144} }