@article{Alkuraishy_Al-Gareeb_Rasheed_2019, title={Nephroprotective effect of Curcumin (Curcuma Longa) in acute nephrotoxicity in Sprague-Dawley rats}, volume={5}, url={https://www.jocms.org/index.php/jcms/article/view/580}, DOI={10.22317/jcms.v5i2.580}, abstractNote={<p><strong>Objective: </strong>The objective of the present study was to evaluate the nephroprotective effect of curcumin in gentamicin induced-nephrotoxicity.<strong> Methods: </strong>Thirty Male Sprague-Dawley rats were used which divided into three groups, Group1 (<em>n</em>=10): Rats treated with distilled water plus normal saline for 12 days. Group2 (<em>n</em>=10): Rats treated with distilled water   plus gentamicin for 12 days.  Group 3(<em>n</em>=10): Rats treated with curcumin plus Gentamicin for 12 days. Blood urea, serum creatinine, malondialdehyde (MDA), kidney injury molecule (KIM-1) and cystatin-c were measured in both control and experimental groups. <strong>Results:</strong> Rats treated with gentamicin   showed nephrotoxicity as evidence by significant elevation in serum creatinine, blood urea, KIM-1, MDA, Cystatin-C sera levels. <strong>Conclusion: </strong>Curcumin produced significant nephroprotective effect in gentamicin induced-nephrotoxicity through modulation of oxidative stress and inflammatory biomarkers.</p>}, number={2}, journal={Journal of Contemporary Medical Sciences}, author={Alkuraishy, Hayder M. and Al-Gareeb, Ali I. and Rasheed, Huda Abdulbaki}, year={2019}, month={Apr.}, pages={122–124} }