@article{Hassan_Khashman_Abdul Qader_Izzat_2017, title={Assessment of Cox2 and CMV in patients with chronic HCV infection}, volume={3}, url={https://www.jocms.org/index.php/jcms/article/view/134}, abstractNote={<p><span class="fontstyle0"><strong>Objective</strong> </span><span class="fontstyle2">This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection.<br></span><span class="fontstyle0"><strong>Methods</strong> </span><span class="fontstyle2">A total of 30 formalin-fxed of parafn-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsies were used as control group used for immunohistochemistry technique (IHC) to study the expression of cyclooxygenase (COX-2) and cytomegalovirus (CMV) in these samples.<br></span><span class="fontstyle0"><strong>Results</strong> </span><span class="fontstyle2">In current study, the results of expression of COX-2 were found in 25 cases (83.3%) of chronic HCV were strongly positive with a signifcant increase at P < 0.001, while the result of CMV expression was detected as brown cytoplasmic membranous staining of cells with<br>positive CMV expression demonstrated in 21 (70.0%) out of 30 cases of chronic HCV infection cases. All control groups were negative for the expression of COX-2 and CMV.<br></span><strong><span class="fontstyle0">Conclusion </span></strong><span class="fontstyle2">This study concludes that COX-2 and CMV participates in the pathogenesis of chronic HCV infection.</span> </p>}, number={9}, journal={Journal of Contemporary Medical Sciences}, author={Hassan, Heba F. and Khashman, Basim M. and Abdul Qader, Omer A. and Izzat, Alaa W.}, year={2017}, month={Mar.}, pages={182–185} }