VitaminD deficiency and hypertension in type 2 diabetic Iraqi patients

Authors

  • Fadhil Jawad Al-Tu’ma Department of Biochemistry, College of Medicine, University of Karbala, Karbala
  • Lina Mohammed Z Yosuf Department of Chemistry, College of Science, University of Maysan, Maysan

DOI:

https://doi.org/10.22317/jcms.v1i1.88

Keywords:

25-(OH) D3, lipid profile, hypertension, T2DM, BMI

Abstract

Objective Vitamin D3 deficiency has been defined as serum 25-hydroxyvitamin D3[25-(OH)D3] levels below 30 ng/ml and it is common among patients with type 2 diabetes mellitus (T2DM). Laboratory studies indicate that 1,25-(OH)D3 suppresses renin expression and vascular smooth muscle cells proliferation, then decreases blood pressure. The aim of the present study is to demonstrate the association between 25-(OH)D3 level and the risk of blood pressure, and its relation with T2DM and body mass index (BMI).
Method This study was conducted at Al-Hussein Medical City/Al-Hussein Teaching Hospital, Karbala, Iraq. All samples, 30 apparently healthy subjects as control, N = 30 and 90 patients (equal number of male and female) with T2DM [50 obese with hypertension (G1) and 40 non-obese without hypertension (G2)], were randomly selected from diabetic patients who had attended the diabetic consultation unit from November 2012 to June 2013 with age ranged between 23 and 75 years. Measurement of 25-(OH)D3, fasting blood glucose, triglyceride, total cholesterol and high-density lipoprotein cholesterol (HDL-C) levels in addition to blood pressure and BMI were calculated in all samples.
Results The results showed that serum 25-(OH)D3 was significantly decreased in G1 and G2 groups (16.8 ± 8.8 ng/ml, 19.5 ± 9.7 ng/ml, respectively), compared with control group (36.0 ± 9.4 ng/ml) at P < 0.001, and 68% of female vs. 57% of male underwent this deficiency. Also 25-(OH)D3 had negative correlation with blood pressure, fasting blood sugar, triglycerides and BMI in diabetic patients in G1 at P < 0.0001 and it had positive significant correlation with HDL-C in G1 and G2 groups.
Conclusion It can be concluded that T2DM, systolic and diastolic blood pressure levels correlates significantly with lower concentration of 25-(OH)D3, which suggested that clinical experiences should be taking into account the protective effect of vitamin D in decrease hypertension, which reflects risk factors in diabetic patients with hypertension that leads to metabolic syndrome and then to cardiovascular diseases.

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Published

2015-03-26

How to Cite

Al-Tu’ma, F. J., & Yosuf, L. M. Z. (2015). VitaminD deficiency and hypertension in type 2 diabetic Iraqi patients. Journal of Contemporary Medical Sciences, 1(1), 17–20. https://doi.org/10.22317/jcms.v1i1.88

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