Correlation Between Programmed Cell Death Ligand1 (PD-L1) Expression and Clinical Parameters in Colorectal Carcinoma.

  • Zainab Waleed Aziz Department of Pathology, Ninevah Medical College, Ninevah University, Mosul, Iraq.
  • Asmaa Mohammadsheet Mahmood Department of pathology, Ninevah Medical College, Ninevah University, Mosul, Iraq.
  • Zahraa Osama Yahiya Department of Pathology, Ninevah Medical College, Ninevah University, Mosul, Iraq.
  • Wahda Mohammed Taib Al –Nuaimy Department of Pathology, College of Medicine, University of Mosul, Nineveh Province, Iraq.

Abstract

Objectives: Programmed Cell Death Ligand1 (PD-L1) tissue expression in CRC (colorectal cancer) displays conflicting results among various studies. We aimed to identify the rate of PD-L1 positivity in colorectal carcinoma, and it's immune infiltrating cells, their relationship with clinicopathologic parameters of patients, and to correlate the results with other studies.
 
 Methods: PD-L1 antibody retrospectively analyzed immunohistochemically in tissue microarray blocks of 99 specimens with colonic and rectal carcinomas operated between January 2015 to December 2017. A comparison performed between PD-L1 expression  in tumor cells (TCs) as well as tumor-infiltrating immune cells (TIICs) for age, sex, histological differentiation, the primary tumor location, number of involved lymph nodes, angiolymphatic invasion, and TNM stage.
 
Results: Of the 99 patients, the median age was 54.5 (range: 18 to 83) years. Fourteen samples were PD-L1 positive in TCs, increased to 32%  in TIICs. A significant expression of PD-L1in TCs was correlated with medullary histology (p= 0.03), number of the involved lymph nodes (p= 0.02), distant metastasis (p= 0.001), and TNM stage (p= 0.0001). The PD-L1 status in TIICs was again connected with adverse clinical and pathological parameters.
 
 Conclusions: The expression of PD-L1 in TCs and TIICs is associated significantly with advanced cancer or lymphatic invasion in patients who underwent surgery after a diagnosis of CRC. The research designates the significance of estimation of TCs and TIICs in correlation to clinicopathologic characteristics of patients a finding that could produce a piece of evidence for precise electing immunotherapy.
 
 
 
Keywords: Programmed cell death ligand1, colorectal carcinoma, Tissue microarray study, Immunohistochemistry.
 
 
 
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Published
2020-08-26
How to Cite
AZIZ, Zainab Waleed et al. Correlation Between Programmed Cell Death Ligand1 (PD-L1) Expression and Clinical Parameters in Colorectal Carcinoma.. Journal of Contemporary Medical Sciences, [S.l.], v. 6, n. 4, aug. 2020. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/810>. Date accessed: 20 oct. 2020. doi: https://doi.org/10.22317/jcms.v6i4.810.