Cystatin-C in patients with acute coronary syndrome: Correlation with ventricular dysfunction, and affected coronary vessels

  • Dhulfiqar Ali Abed (1) Department of Medicinal Chemistry, College of Pharmacy, University of Babylon, Babylon, Iraq.
  • Raad Jasim (2) Pharmacology and Therapeutics, Monash Institute of Pharmaceutical Sciences, Faculty of pharmacy and pharmaceutical sciences, Monash University, Australia; (3) Department Pharmacology and Therapeutics, College of Pharmacy, University of Babylon, Babylon, Iraq.
  • Hayder Abdul-Amir Al-Hindy (4) Pharmacology & toxicology Department, College of Pharmacy, University of Babylon, Babylon, Iraq.
  • Ammar Waheeb Obaid

Abstract

Abstract
Objective: This study designed to inspect the circulating levels of Cy/C in patients with ACS and to evaluate the association of Cy/C levels with ejection fraction and angiographic number of stenosed coronaries.
Methods: 136 participants with ACS were enrolled in this case-control survey and compared with 94 control. Hematological assessments were done for all the participants and included Cy/C, creatinine and uric acid were measured using conventional technique. Creatinine clearance rate was calculated and Estimated glomerular-filtration-rate (eGFR) were measured. Echocardiographic assessment of ejection fraction was done with a cut-off-point <40 LVEF% designated for LV systolic dysfunction. Angiographic evaluation involved in this study depending on the severity of stenosed coronaries by calculating number of arteries display not less than 1 critical stenosis (designed as >70% decrease in caliber).
Results: Ejection fraction was significantly lower in in ACS patients than control group (p<0.05). Serum Cy/C was significantly higher in patients' group. The mean plasma uric acids values were significantly higher in patients' group (p-0.001) but with no significant differences in creatinine and creatinine clearance (p>0.05) observed between groups. The eGFR were significantly lower in ACS people compared to healthy persons. Correlation studies of Cy/C showed positive correlation with serum creatinine and serum uric acid; as well as non-significant negative correlation with eGFR (p>0.05).
Conclusion: Besides the role of Cy/C in early detection of renal dysfunction, it could have a role in diagnosis of ACS and evaluation of LV systolic dysfunction. Nevertheless, this study showed Cy/C was not related to the number of coronary arteries affected.
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Published
2020-02-26
How to Cite
ABED, Dhulfiqar Ali et al. Cystatin-C in patients with acute coronary syndrome: Correlation with ventricular dysfunction, and affected coronary vessels. Journal of Contemporary Medical Sciences, [S.l.], v. 6, n. 1, feb. 2020. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/729>. Date accessed: 13 july 2020.