A Case Report of Gorlin-goltz Syndrome

  • Shima Nafarzadeh Assistant Professor, Department of Oral and Maxillofacial Pathology, Dentistry School, Babol University of Medical Sciences, Babol, Iran.
  • Fatemeh Mozaffari Faculty, Department of Oral and Maxillofacial Pathology, Dentistry School, Mazandaran University of Medical Sciences, Sari, Iran.
  • Oveis Khakbaz Assistant Professor, Department of Oral and Maxillofacial Surgery, Dentistry School, Babol University of Medical Sciences, Babol, Iran.

Abstract

Nevoid basal cell carcinoma syndrome (Gorlin syndrome) is an autosomal dominant inherited condition that exhibits high penetrance and variable expressivity. The syndrome is caused by mutations in patched (PTCH), a tumor suppressor gene that has been mapped to chromosome 9q22.3-q31. Gorlin-goltz syndrome (GGS) is characterised by the presence of multiple odontogenic keratocysts in the jaws, basal cell carcinomas, palmar and plantar pits and intracranial calcifications. Here, we present a case of familial GGS, characterised by multiple odontogenic keratocysts, broad nasal ridge, hypertelorism, enlarged head circumference and dermoid cysts.
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Published
2016-04-13
How to Cite
NAFARZADEH, Shima; MOZAFFARI, Fatemeh; KHAKBAZ, Oveis. A Case Report of Gorlin-goltz Syndrome. Journal of Contemporary Medical Sciences, [S.l.], v. 2, n. 5, p. 33-35, apr. 2016. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/65>. Date accessed: 26 may 2017.
Section
Case Report

Keywords

dermoid cyst, Gorlin-goltz syndrome, odontogenic cysts