Comparison of the effect of dexmedmotidine and ketamine on controlling pain after cesarean section via intra-peritoneal method

dexmedmotidine and ketamine on controlling pain after cesarean section

  • Alireza Kamali Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak, Iran
  • Maryam Maktabi Department of Gynecology, Arak University of Medical Sciences, Arak, Iran
  • Zoha Khademi Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak, Iran
  • Taha Fereidooni Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak, Iran

Abstract

Introduction: Pain is a completely mental experience, which produces adverse hemodynamic and metabolic responses in patients. Postoperative pain has some deleterious effects. One of the most common surgeries is cesarean section. This surgery is associated with acute postoperative pain that causes unpleasant psychological responses such as anxiety, sadness, aggression, insomnia, and lack of logical connection with the physician and nurse. Therefore, the present study aimed to compare the effect of dexmedmotidine and ketamine on controlling pain after cesarean section via intra-peritoneal method.
Materials and Methods: In this clinical and double-blind clinical trial, patients were randomly divided into two groups (dexmedmotidine and ketamine). In the first group, 5 mg / kg ketamine and 1 mg / kg dexmedetomidine were injected in 100 mg normal saline. Pain score was measured on the basis of the visual analog pain scale during the recovery at 4, 6 and 12 hours after the surgery. The data were then analyzed by SPSS (version 20).
Results: 70 patients participated in the study. The results showed that the mean pain scores were the same in different postoperative hours in patients (P≥0.05). The mean opioid use in the ketamine group was lower than inter-peritoneal dexmedmotidine (P = 0.03). Moreover, the mean postoperative analgesia in the ketamine group was higher than inter-peritoneal dexmedmotidine (P = 0.04).
Conclusion: According to the results, the mean opioid consumed in the ketamine group was less than inter-peritoneal dexmedmotidine. Additionally, the mean postoperative analgesia in the ketamine group was higher than that of inter-peritoneal dimethomidine. Therefore, it can be concluded that ketamine has a better effect on reducing pain after cesarean section.
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Published
2019-09-05
How to Cite
KAMALI, Alireza et al. Comparison of the effect of dexmedmotidine and ketamine on controlling pain after cesarean section via intra-peritoneal method. Journal of Contemporary Medical Sciences, [S.l.], v. 5, n. 4, sep. 2019. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/598>. Date accessed: 17 nov. 2019.
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