Nephroprotective effect of Curcumin (Curcuma Longa) in acute nephrotoxicity in Sprague-Dawley rats

  • Hayder M. Alkuraishy Department of clinical Pharmacology, Medicine and Therapeutic, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq
  • Ali I. Al-Gareeb Department of clinical Pharmacology, medicine and therapeutic, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
  • Huda Abdulbaki Rasheed Department of clinical Pharmacology, medicine and therapeutic, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.

Abstract

Objective: The objective of the present study was to evaluate the nephroprotective effect of curcumin in gentamicin induced-nephrotoxicity. Methods: Thirty Male Sprague-Dawley rats were used which divided into three groups, Group1 (n=10): Rats treated with distilled water plus normal saline for 12 days. Group2 (n=10): Rats treated with distilled water   plus gentamicin for 12 days.  Group 3(n=10): Rats treated with curcumin plus Gentamicin for 12 days. Blood urea, serum creatinine, malondialdehyde (MDA), kidney injury molecule (KIM-1) and cystatin-c were measured in both control and experimental groups. Results: Rats treated with gentamicin   showed nephrotoxicity as evidence by significant elevation in serum creatinine, blood urea, KIM-1, MDA, Cystatin-C sera levels. Conclusion: Curcumin produced significant nephroprotective effect in gentamicin induced-nephrotoxicity through modulation of oxidative stress and inflammatory biomarkers.
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Published
2019-05-03
How to Cite
ALKURAISHY, Hayder M.; AL-GAREEB, Ali I.; RASHEED, Huda Abdulbaki. Nephroprotective effect of Curcumin (Curcuma Longa) in acute nephrotoxicity in Sprague-Dawley rats. Journal of Contemporary Medical Sciences, [S.l.], v. 5, n. 2, may 2019. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/580>. Date accessed: 19 aug. 2019.
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