Protective effect of sildenafil in pulmonary hypertensive child with congenital heart disease
AbstractObjective Pulmonary hypertension has been described as an elevation in mean pulmonary artery pressure (PAP) >25 mmHg at rest or 30 mmHg during exercise, which can be classified into primary and secondary pulmonary hypertension.Methods In this study, subjects were divided into two groups of patients and controls. The patients were treated with Sildenafil for 3 months, starting with 0.2 mg/kg/dose, six times daily and then the dose was increased with an increment of 0.2 mg/kg/dose every 15 days. Echocardiography examination, including pulmonary artery pressure, tricuspid regurgitation velocity, and pulmonary artery acceleration time, as well as oxygen saturation (SpO2) rate were measured every 15 days.Results The results revealed that a significant decrease (P < 0.05) in the pulmonary artery and tricuspid pressure, and a significant increase (P < 0.05) in the rate of blood oxygen saturation and pulmonary artery acceleration time have been found.Conclusion The results of this study reveal that Sildenafil has a great effect in the treatment of the secondary type of pulmonary hypertension and has a negligible effect on primary pulmonary hypertension.
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