Preparation of nanohybrid compound from the drugs (naproxen and cephalexin) with zinc oxide and studying biological activities against Aeromonas bacteria

Abstract

Objectives This study focus on the preparation of the compound nanoscale layers of Zinc oxide (ZnO) with naproxen and cephalexin.Methods Ion exchange technique via sol-gel method synthesised under aqueous environment, resulted in the formation of inorganic organiccharacteristics of nanohybrid by using X-ray diffraction (XRD) method and study antibacterial activity of hybrid and free compound againstsome bacteria.Results The powder X-ray diffraction showed new level for nanohybrid compounds differ from free compounds. The antibacterial resultsshow more nanohybrid compounds concentration increased its effectiveness against bacteria, the greater the concentration of thecompound greater is the increase in its effectiveness against bacteria inhibitory.Conclusions The possibility of the bind of drugs (Cephalexin and Naproxen) in the preparation of nanohybrid-ZnO compound and the useof nanocompounds as antibacterial agent in better treatment of pathogenic bacteria. And this nanocompound is more efficient from freecompounds.