Efficacy and safety of micro/nanostructured polymeric coatings for drug eluting stents

  • Mostafa Rahvar Department of Medical Nanotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences, Tehran, Iran
  • Gholamreza Ahmadi Lakalayeh Department of Medical Nanotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences, Tehran, Iran
  • Reza Faridi majidi Department of Medical Nanotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences, Tehran, Iran
  • Ismaeil Haririan Medical Biomaterial Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Bahereh T. Marouf Department of Materials Science and Engineering, Faculty of Engineering, Urmia University, Urmia, Iran
  • Hossein Ghanbari Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Objectives: Efficacy of a polymeric coating for drug eluting stents depends on its safety and structural properties. Today, it is well known that factors such surface texture, morphology and drug release kinetics are among the most critical factors that determines the ultimate destiny and success of drug eluting stents. Therefore, the ability to design and control these critical properties guarantee the success of DES in the body.
Methods: In this study, two different micro/nanostructured coatings was prepared using poly lactic acid and dexamethasone by electrohydrodynamic atomization (EHDA) and spinning as coating methods. To analyze structural properties of coatings different technique was used including:   X-ray diffraction (XRD), scanning electron microscopy (SEM) and confocal microscopy. Platelet, neutrophil and peripheral blood mononuclear cell adhesion was studied to evaluate safety of coatings. Then, antibacterial properties of coatings were considered. Finally, Drug release profile was evaluated for 15 days.
Results: The results showed that suitable surface properties of micro/nanostructured coatings led to very low platelet, neutrophil, PBMN on the surfaces. Micro/nanostructured coatings showed two drug release kinetics that are applicable for different drug delivery systems.
Conclusion: Based on the results, EHDA method have great potential as a coating method for drug eluting stents.
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Published
2018-09-26
How to Cite
RAHVAR, Mostafa et al. Efficacy and safety of micro/nanostructured polymeric coatings for drug eluting stents. Journal of Contemporary Medical Sciences, [S.l.], v. 4, n. 3, sep. 2018. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/456>. Date accessed: 14 dec. 2018.
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Articles