Relationship between serine/threonine kinase 39 gene polymorphisms with some cardiac biomarkers in hypertensive patients

  • Fadhil Jawad Al-Tu’ma Deparment of Biochemistry, College of Medicine, University of Karbala
  • Zena Abdul-Ameer Mahdi Deparment of Biochemistry, College of Medicine, University of Karbala
  • Hassan Mahmood Abo Almaali Branch of Clinical Laboratory Science, College of Pharmacy, University of Karbala

Abstract

Aim This study aimed to evaluate the association between STK39 SNP rs35929607 and some cardiovascular risk factors in hypertensionpatients in holy Kerbala city, Iraq.Materials and Methods We included 74 hypertensive patients with no signs and symptoms of renal impairment and another 30 control subjects.The links between genotype and hypertension were examined. Then, the SNP related variances in the blood pressure and remainingcardiovascular risk factors were studied.Results There is no significant association between STK39 rs35929607 and hypertension in current study. However Allele A showed asignificant association in hypertensive patient compared with control group particularly in female gender. The hypertensive patientsshowed a significant higher result in age, BMI, FBS, total cholesterol, and STG, LDL-C and lower level in HDL-C.Conclusion The association between the SNP rs35929607ofSTK3 and hypertension was not significant in current study in Kerbala populationof Iraq. Furthermore, only Allele A showed a significant association with hypertension in females group. Further studies needed to clarifythe effect of other STK39 variants on these cardiovascular risk factors.
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Published
2016-01-08
How to Cite
AL-TU’MA, Fadhil Jawad; MAHDI, Zena Abdul-Ameer; ABO ALMAALI, Hassan Mahmood. Relationship between serine/threonine kinase 39 gene polymorphisms with some cardiac biomarkers in hypertensive patients. Journal of Contemporary Medical Sciences, [S.l.], v. 1, n. 4, p. 1-6, jan. 2016. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/44>. Date accessed: 26 may 2017.
Section
Articles

Keywords

hypertension, BMI, STK39 , LDL-C, polymorphism