PMSG and HCG hormones effect on the development and growth of ovarian follicles

  • Masoumeh Majidi Zolbin Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Sepidah Nematin Department of Obstetrics and Gynecology, Yale School of Medicine, New Haven, USA.
  • Faezeh Daghigh Department of Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Fariba Namdar Department of Physiology, School of Medicine, Baqiyatollah University of Medical Sciences, Tehran, Iran.
  • Mahmoodreza Madadian Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
  • Mahdi Abbasi Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Mohammad Hosein Noori Mogahi Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Nasrin Takzaree Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Objective Gonadotropins are generally used in animals and humans to stimulate ovulation and increase the number of available oocytesfor techniques such as in vitro fertilization. Ovulation-inducing drugs are used to achieve multiple oocytes in one cycle, thereby increasingthe chances of pregnancy in patients with infertility. The aim of this study was to evaluate the effect of gonadotropins on stimulation ofovulation and their inductive role on the growth and development of follicles in the ovary.Methods To determine the effect of human chronic gonadotrophin (HCG) and pregnant mare serum gonadotrophin (PMSG) on ovary, thisstudy used 20 rats that were randomly divided to experimental and control groups. Rats were subsequently euthanized 48 h after injectionand the ovaries were fixed and stained with H&E. Data were analyzed with Tukey’s multiple comparisons with one-way ANOVA test inGraphPad Prism software.Result Our analysis demonstrated that HCG and PMSG hormones will significantly increase the number of stimulated oocyte in the ovarybut it does not have any significant role on the ovary weight and volume (P < 0.05).Conclusion This study’s results confirmed the inductive role of PMSG and HCG hormones on folliculogenesis.
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Published
2018-03-26
How to Cite
ZOLBIN, Masoumeh Majidi et al. PMSG and HCG hormones effect on the development and growth of ovarian follicles. Journal of Contemporary Medical Sciences, [S.l.], v. 4, n. 1, mar. 2018. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/340>. Date accessed: 19 aug. 2018.
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