Assessment of Cox2 and CMV in patients with chronic HCV infection

  • Heba F. Hassan Department of Basic Sciences, College of Dentistry, University of Baghdad
  • Basim M. Khashman Iraqi national cancer research center (INCRC), University of Baghdad
  • Omer A. Abdul Qader Kulliyyah of Dentistry oral medicine and oral pathology Department, International Islamic University Malaysia
  • Alaa W. Izzat College of Dentistry, University of Baghdad

Abstract

Objective This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection.Methods A total of 30 formalin-fxed of parafn-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsies were used as control group used for immunohistochemistry technique (IHC) to study the expression of cyclooxygenase (COX-2) and cytomegalovirus (CMV) in these samples.Results In current study, the results of expression of COX-2 were found in 25 cases (83.3%) of chronic HCV were strongly positive with a signifcant increase at P < 0.001, while the result of CMV expression was detected as brown cytoplasmic membranous staining of cells withpositive CMV expression demonstrated in 21 (70.0%) out of 30 cases of chronic HCV infection cases. All control groups were negative for the expression of COX-2 and CMV.Conclusion This study concludes that COX-2 and CMV participates in the pathogenesis of chronic HCV infection.
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Published
2017-03-26
How to Cite
HASSAN, Heba F. et al. Assessment of Cox2 and CMV in patients with chronic HCV infection. Journal of Contemporary Medical Sciences, [S.l.], v. 3, n. 9, p. 182-185, mar. 2017. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/134>. Date accessed: 30 may 2017.
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