Measurement of urinary kidney injury molecule-1 as a predictive biomarker of contrast-induced acute kidney injury

  • Fadhil Jawad Al-Tu’ma Department of Biochemistry, College of Medicine, University of Kerbala
  • Maha Hamood Dheyauldeen Department of Biochemistry, College of Medicine, University of Kerbala
  • Ryiadh Mohi Al-Saegh Department of Nephrology, College of Medicine, University of Kerbala

Abstract

Objective The aim of the present study is to evaluate the urinary KIM-1 level in the patients after 24 h angiography as a predictive biomarker of contrast-induced acute kidney injury.Methods This study included 80 selective patients attending in the cardiology unit (48 males, 32 females). The study was conducted in the cardiac catheterization unit at Al- Hussein Medical City/ Kerbala. Clinical examination and laboratory investigations were made before and 24 h after angiography, these investigations include: serum creatinine, blood urea and estimated GFR. Urinary KIM-1 was measured before and after 24 h angiography.Results There was no signifcant difference in urinary KIM-1 when compared between CIN and non CIN group P > 0.05. The level of urinary KIM-1 increased in the patients after 24 h of angiography when compared with baseline level of P < 0.001.Conclusion Urinary KIM-1 was not useful for predicting or detecting CIN. But urinary KIM-1 level may be useful as a biomarker for tubular damage following intravascular administration of contrast media, 24 h.
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Published
2017-03-26
How to Cite
AL-TU’MA, Fadhil Jawad; DHEYAULDEEN, Maha Hamood; AL-SAEGH, Ryiadh Mohi. Measurement of urinary kidney injury molecule-1 as a predictive biomarker of contrast-induced acute kidney injury. Journal of Contemporary Medical Sciences, [S.l.], v. 3, n. 9, p. 178-181, mar. 2017. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/133>. Date accessed: 24 nov. 2017.
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