Bioremediation of Zearalenone by using Lactobacillus acidophilus in albino rats bodies (in vivo)
AbstractObjective This study aimed to evaluate the efficiency of Lactobacillus acidophilus to reduce zearalenone toxicity in vital systems of albinowhite rats.Methods Fusarium graminearum isolate was tested to produce zearalenone toxin. L. acidophilus was used to reduce the toxin in rats. Thisability was studied by many parameters such as biochemical and physiological parameters in addition to histological study.Results The results showed that L. acidophilus had the ability to reduce zearalenone toxicity. L. acidophilus had the ability to raise Hb 11 g/dlin blood of animals that was treated with zearalenone only to 13.06 g/dl in animal’s blood that was treated with zearalenone + L. acidophilus.As well as the number of red blood cells in animals blood treated with these treatment was 6.62 × 1012 cell/ L. L. acidophilus reduces thetoxicity of zearalenone through its ability to reduce the number of platelets to normal levels.Conclusion L. acidophilus had a role in repeated biochemical parameters to normal levels. Total protein rose to 6.6 g/dl in animal’s bloodtreated with zearalenone + L. acidophilus compared with these levels in blood of control group. Also GPT and sugar levels in animal bloodthat was treated with zearalenone + L. acidophilus were at normal level. Histological study proved that L. acidophilus had the ability toprotect liver, kidney, and uterus from the toxicity of zearalenone.
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