Ajwa seeds (Phoenix dactylifera L.) suspension exerted antidiabetic and antihyperlipidemic effects against streptozotocin-induced diabetes in rats by downregulating insulin expression in the pancreatic beta islets

  • Ahlam Abdulaziz Alahmadi Department of Biological Sciences, College of Science, King Abdulaziz University, Jeddah, Saudi Arabia. http://orcid.org/0000-0001-7240-6278
  • Hessah Mohammed Banayah Department of Biological Sciences, College of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Abstract

Objectives: This study investigated the antidiabetic and antihyperlipidemic effects of the powdered seeds of Ajwa Al-Madina in streptozotocin (STZ)-induced diabetes in rats. Besides investigating the possible underlying mechanisms.
Methods: Rats were assigned to one of six groups (n = 5) as follows: normal control, vehicle control, Ajwa seeds control, diabetic control, Diabetic + Metformin, and Diabetic + Ajwa seeds. Metformin and Ajwa seeds were injected into rats orally via oral gavage 6 days/week along 4 weeks period
Results: Ajwa seeds decreased fasting serum glucose, increased fasting serum insulin and decreased fasting serum triglycerides cholesterol, low-density lipoprotein, and increased fasting serum high-density lipoprotein. Besides, it upregulated insulin protein immunoexpression in the beta cells of Langerhans islets. Ajwa seed also preserved the normal histological structure of the pancreatic beta cells tissue.
Conclusion: Ajwa seeds produced significant hypoglycemic and hypolipidemic effects in diabetic rats mainly through enhancement of insulin secretion. The plant is a promising adjunctive therapy in diabetes mellitus treatment.
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Published
2021-08-26
How to Cite
ALAHMADI, Ahlam Abdulaziz; BANAYAH, Hessah Mohammed. Ajwa seeds (Phoenix dactylifera L.) suspension exerted antidiabetic and antihyperlipidemic effects against streptozotocin-induced diabetes in rats by downregulating insulin expression in the pancreatic beta islets. Journal of Contemporary Medical Sciences, [S.l.], v. 7, n. 4, aug. 2021. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/1058>. Date accessed: 16 sep. 2021. doi: https://doi.org/10.22317/jcms.v7i4.1058.