Efficacy of Hawthorn fruit extract on blood pressure and quality of sleep in patients with hypertension along with sleep disorders: A randomized double-blind controlled trial

  • Masumeh Abbasi Department of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  • Sepehr Gohari Student Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  • Hassan Ahangar Department of Cardiology, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. http://orcid.org/0000-0001-8183-1188
  • Mohsen Bahrami Department of Persian Medicine, Academic Center for Education, Culture and Research Center, Tehran, Iran.
  • Mohammad Kamalinejad Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Tara Reshadmanesh Student Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Seyede Shadi Nazari Department of Biostatistics, School of medicine, Zanjan university of Medical Sciences, Zanjan, Iran.

Abstract

Objective: This study aimed to investigate the effect of Crataegus monogyna (C.monogyna) on controlling the blood pressure in patients with hypertension along with sleep disorder.
Methods: This was a parallel double-blind, placebo-controlled trial study from May, 2018 to December, 2019. Total of 60 patients with hypertension and sleep disorder were randomly assigned to C.monogyna and placebo groups. The groups received C.monogyna and placebo capsules twice-daily for 8 weeks. The primary outcomes were the changes of systolic and diastolic blood pressure and Pittsburgh questionnaire’s scores from baseline measurements. The secondary outcomes were changes in serum biochemical markers from baseline.
Results: Before treatment, there was no significant difference between study groups in terms of demographic data and outcomes (P>0.05) except body mass index (P=0.02). After treatments, the intervention group had a significant improvement in systolic and diastolic blood pressure compared to placebo ((118.14±6.76 vs 129.76±8.28, 95% CI: 7.54 – 15.69, P<0.001 and 77.14±5.32 vs 83.57±6.73, 95% CI: 3.17 – 9.68, P<0.001, respectively) analysis revealed no significant difference observed between study groups in terms of baseline characteristics and pre-and posttreatment laboratory tests. Also, none of the groups had superiority in terms of the Pittsburgh questionnaire’s scores (P=0.44); however, the intragroup analysis revealed significant improvements in the intervention group (P= 0.001).
Conclusion: C.monogyna fruit extract as a supplementary medication has beneficial effects on controlling blood pressure and quality of sleep in patients with hypertension along with sleep disorders.
share this Article by

References

1. Stamler J, Stamler R, Neaton JD, Wentworth D, Daviglus ML, Garside D, et al. Low risk-factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adult and middle-aged men and women. Jama. 1999;282(21):2012-8.
2. Forouzanfar MH, Liu P, Roth GA, Ng M, Biryukov S, Marczak L, et al. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015. Jama. 2017;317(2):165-82.
3. Dardi F, Palazzini M, Gotti E, Zuffa E, De Lorenzis A, Daniele G, et al. Additional Role of Unmodifiable Risk Factors in Pulmonary Arterial Hypertension Risk Stratification According to Current ESC/ERS Guidelines. Circulation. 2019;140(Suppl_1):A9541-A.
4. Daştan İ, Erem A, Çetinkaya V. Urban and rural differences in hypertension risk factors in Turkey. Anatol J cardiol. 2017;18(1):39.
5. Pandey R, Quan WY, Hong F. Vaccine for hypertension: modulating the renin–angiotensin system. Int J cardiol. 2009;134(2):160-8.
6. Dabaghian FH, Rassouli M, Sadighi J, Ghods R. Adherence to prescribed medications of Iranian traditional medicine in a group of patients with chronic disease. J Res Pharm Pract. 2016;5(1):52.
7. Ibn Sina H. The Canon of medicine. Beirut: Alaalamy Foundation Publications. 2005.
8. Calhoun D. Sleep disorders and hypertension risk. J Hum Hypertens. 2017;31(6):371-2.
9. Calhoun DA. Obstructive sleep apnea and hypertension. Curr. Hypertens. Rep. 2010;12(3):189-95.
10. Calhoun DA, Harding SM. Sleep and hypertension. Chest. 2010;138(2):434-43.
11. Fiorentini A, Valente R, Perciaccante A, Tubani L. Sleep's quality disorders in patients with hypertension and type 2 diabetes mellitus. Int J Cardiol. 2007;114(2):E50-E2.
12. Seravalle G, Mancia G, Grassi G. Sympathetic nervous system, sleep, and hypertension. Curr. Hypertens. Rep. 2018;20(9):74.
13. Gangwisch JE, Malaspina D, Posner K, Babiss LA, Heymsfield SB, Turner JB, et al. Insomnia and sleep duration as mediators of the relationship between depression and hypertension incidence. Am J Hypertens. 2010;23(1):62-9.
14. MH AK. Makhzan-ol-advieh. Tehran: Sabz arang publication. 2008.
15. Alirezalu A, Ahmadi N, Salehi P, Sonboli A, Alirezalu K, Mousavi Khaneghah A, et al. Physicochemical characterization, antioxidant activity, and phenolic compounds of Hawthorn (Crataegus spp.) fruits species for potential use in food applications. Foods. 2020;9(4):436.
16. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry res. 1989;28(2):193-213.
17. Baddeley-White DS, McGowan CL, Howden R, Gordon BD, Kyberd P, Swaine IL. Blood pressure lowering effects of a novel isometric exercise device following a 4-week isometric handgrip intervention. Open Access J Sports Med. 2019;10:89.
18. Ghorbani M. Iranian traditional medicine for treatment of type II diabetes, anxiety and hypertension with introduction of zebrafish model system for their screening. Int J Herb Med. 2014;2(5):13-9.
19. Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med. 2002;113(9):71-88.
20. Sato K, Dohi Y, Kojima M, Miyagawa K, Takase H, Katada E, et al. Effects of ascorbic acid on ambulatory blood pressure in elderly patients with refractory hypertension. Arzneimittelforschung. 2006;56(07):535-40.
21. Haydari MR, Panjeshahin MR, Mashghoolozekr E, Nekooeian AA. Antihypertensive effects of hydroalcoholic extract of crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension: an experimental mechanistic study. Iran J Med Sci. 2017;42(3):266.
22. Renda G, Özel A, Barut B, Korkmaz B, Yayli N. In Vitro Protection by Crataegus microphylla Extracts Against Oxidative Damage and Enzyme Inhibition Effects. Turkish J Pharm. Sci. 2018;15(1).
23. Sharifi N, Souri E, Ziai SA, Amin G, Amanlou M. Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay. DARU J Pharm Sci. 2013;21(1):74.
24. Wang J, Xiong X, Yang G, Zhang Y, Liu Y, Zhang Y, et al. Chinese herbal medicine qi ju di huang wan for the treatment of essential hypertension: a systematic review of randomized controlled trials. Evid Based Complement Alternat Med 2013;2013.
25. Hernández-Pérez A, Bah M, Ibarra-Alvarado C, Rivero-Cruz JF, Rojas-Molina A, Rojas-Molina JI, et al. Aortic relaxant activity of Crataegus gracilior Phipps and identification of some of its chemical constituents. Molecules. 2014;19(12):20962-74.
26. Shatoor AS. Acute and sub-acute toxicity of Crataegus aronia syn. azarolus (L.) whole plant aqueous extract in wistar rats. Am J Pharmacol Toxicol. 2011;6(2):37-45.
Published
2021-08-26
How to Cite
ABBASI, Masumeh et al. Efficacy of Hawthorn fruit extract on blood pressure and quality of sleep in patients with hypertension along with sleep disorders: A randomized double-blind controlled trial. Journal of Contemporary Medical Sciences, [S.l.], v. 7, n. 4, p. 196-201, aug. 2021. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/1017>. Date accessed: 21 oct. 2021. doi: https://doi.org/10.22317/jcms.v7i4.1017.