Interleukin-8 251- A/T polymorphism related to peptic ulcer disease in H. pylori infected patient

  • Israa Saeed Abbas Department of Clinical Laboratories, College of Applied Medical Sciences, Karbala University, Iraq.

Abstract

Objectives This study includes the investigation of antifungal activity of the local propolis against dermatophytes and yeast.Methods A total of 92 tissue samples were taken from patients infected with H. pylori and 102 from uninfected individuals has been included. Genetic method used for the detection of H. pylori infection by polymerase chain reaction (PCR) for glM gene identification. IL-8- 251 A/T polymorphism was detected by allele-specific oligonucleotide polymerase chain reaction (ASO- PCR).Results Among the studied samples, the results improve that genetic polymorphism of IL-8-251 A/T genotype was found in a higher frequency with confidence interval 95% in duodenal ulcer H. pylori infected patient than control.Conclusion IL-8-251 A allele notice that it has been associated with severe inflammation lead to increase severity of disease.
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Published
2016-12-23
How to Cite
ABBAS, Israa Saeed. Interleukin-8 251- A/T polymorphism related to peptic ulcer disease in H. pylori infected patient. Journal of Contemporary Medical Sciences, [S.l.], v. 2, n. 8, p. 138-140, dec. 2016. ISSN 2413-0516. Available at: <http://www.jocms.org/index.php/jcms/article/view/101>. Date accessed: 07 aug. 2020.
Section
Articles

Keywords

Helicobacter pylori, molecular biology (PCR), allele-specific oligonucleotide