The role of biochemical markers in the assessment of Non-alcoholic fatty liver disease in young Iraqi people

  • Shahad A. Qassam Department of Biochemistry, College of Medicine, University of Karbala, Karbala, Iraq.
  • Zaid K. Ahmed Department of Anatomy, College of Medicine, University of Karbala, Karbala, Iraq.
  • Shaymaa Z. Nada Department of Biochemistry, College of Medicine, University of Karbala, Karbala, Iraq.

Abstract

Objectives: to study clinical diagnostic markers and prognostic biochemical markers which will help to evaluate of Nonalcoholic fatty liver disease in Iraqi Young adult.
Method: a total of 816 patients referred for ultrasound  checking, their aged (18-40) years they were studied to detect the prevalence of NAFLD. For comparison of level of CK18 and other studied markers, we choose 45 patients with NAFLD, From the remaining standard individuals, we randomly selected 45 individuals as control group. Blood sample was collected to measured lipid profile, liver enzyme and CK-18, Enzyme-linked immune sorbent assay (ELISA) used for detecting and quantifying inflammatory markers.
Results: show that serum CK-18 was highly significant in patient with non-alcoholic fatty liver disease when comparison with control groups (P = 0.001), also showed Fatty Liver Index (FLI) values were significantly higher in patient with NALD than in control group (P =0.001), showed markedly great diagnostic accuracy (AUROC curve: 0.968).
Conclusion, our result indicates from results of inflammatory markers most patients in this study with steatohepatitis, FLI is most sensitive diagnostic marker for diagnostic NAFLD.
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Published
2019-09-14
How to Cite
QASSAM, Shahad A.; AHMED, Zaid K.; NADA, Shaymaa Z.. The role of biochemical markers in the assessment of Non-alcoholic fatty liver disease in young Iraqi people. Iraq Medical Journal, [S.l.], v. 3, n. 2, sep. 2019. ISSN 2521-8492. Available at: <http://www.jocms.org/index.php/imj/article/view/638>. Date accessed: 20 nov. 2019.
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Articles