Efficacy of Intra-Articular Injection of Activated Platelet Rich Plasma as Pain Management Method in Chronic Knee Pain

  • Abdullah Ahmed Mohammad Department of Family Medicine, Azadi Teaching Hospital, Kirkuk, Iraq
  • Hayder Ghali Wadi Algawwam Department of Emergency Medicine, ONG Onlus, Sulaymaniyah, Iraq

Abstract

Objective The aim of this retrospective study is to evaluate the efficacy of IA-PRP in managing the chronically painful knees with OA in a private clinic in Kirkuk, Iraq.
Methods Over an 18-month period (July 1, 2016- December 31, 2017), 76 patients (57 females) visited us because of painful knees due to OA. 124 knees received IA injections of ozonized PRP (OPRP). The PRP was prepared by centrifuging patients’ own blood and activated by passing 1 ml of ozone for each 1 ml of PRP. A questionnaire was used to categorize the pain into mild, moderate, and severe and the response to therapy was graded as excellent, good, fair and poor.
Results The mean age was 53.6± 1.7 years. 59.2% of females had a moderate pain. Overall, IA-PRP injection yielded excellent-good results in (88.7%) of the treated joints. More than half (n=53, 66.3%) of the well-responded joints received 1-4 doses of IA-OPRP. 
Conclusion IA-PRP seems to be an effective, safe and cheep method for relieving the chronic pain of knee OA.
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References

1. Joshi JN, Rodriguez L, Reverte-Vinaixa MM. Platelet-rich plasma injections for advanced knee osteoarthritis: a prospective, randomized, double-blinded clinical trial. Orthop J Sports Med 2017; 5(2): 2325967116689386.
2. Finan PH, Buenaver LF, Bounds SC, Hussain S, Park RJ, Haque UJ. Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization. Arthritis Rheum 2013;65:363–72.
3. Felson DT. The sources of pain in knee osteoarthritis. Curr Opin Rheumatol 2005;17(5):624–28.
4. Laver L, Marom N, Dnyanesh L, Mei-Dan O, Espregueira-Mendes J , Gobbi A. PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies. SAGE Journals, Cartilage 2016; 8(4): 341–364.
5. Akeda K, An HS, Okuma M, Attawia M, Miyamoto K, Thonar EJ. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthritis Cartilage 2006;12(12):1272-80.
6. Spreafico A, Chellini F, Frediani B, Bernardini G, Niccolini S, Serchi T. Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes. J Cell Biochem 2009;108(5):1153-65.
7. Bhattacharya V, Hansrani M, Wyatt MG, Lambert D, Jones DN. Outcome
following surgery for thoracic outlet syndrome. Eur J Vasc Endovasc Surg
2003;26:170–175.
8. Mohammad AA. Clinical applications of ozone: a review of 94 cases from Iraq. Iraq Med J 2018;2(1):10–14
9. Zelman DC, Dukes E, Brandenburg N, Bostrom A, Gore M. Identification of cut-points for mild, moderate and severe pain due to diabetic peripheral neuropathy. Pain 2005;115:29–36.
10. Muralidhara V, Mamatha SV. Occupational risk factors in knee osteoarthritis. Journal of evidence based medicine and healthcare 2015;2(58):8919-8920.
11. Zang CH, Zeng QY, Li XF, Dong HY, Zhang AL, Zhao Q. A cross-sectional population survey of knee osteoarthritis in Taiyuan region. Zhonghua Nei Ke Za Zhi 2006;45(7):533-6.
12. Vasilic-Brasnjevic S, Marinkovic J, Vlajinac H, Vasiljevic N, Jakovljevic B, Nikic M, Maksimovic M. Association of body mass index and waist circumference with severity of knee osteoarthritis. Acta Reumatol Port. 2016;41(3):226-231.
13. Gabriella M van Dijk, Cindy Veenhof, Francois Schellevis, Harry Hulsmans, Jan PJ Bakker, Henk Arwert, Jos HM Dekker, Guus J Lankhorst and Joost Dekker. Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord 2008;9:95.
14. Di Yalong, Han Changxu, Zhao Liang, Ren Yizhong. Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trials. Arthritis Research & Therapy 2018; 20:128
Published
2018-12-26
How to Cite
MOHAMMAD, Abdullah Ahmed; ALGAWWAM, Hayder Ghali Wadi. Efficacy of Intra-Articular Injection of Activated Platelet Rich Plasma as Pain Management Method in Chronic Knee Pain. Iraq Medical Journal, [S.l.], v. 2, n. 4, dec. 2018. ISSN 2521-8492. Available at: <http://www.jocms.org/index.php/imj/article/view/532>. Date accessed: 23 mar. 2019.
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Articles