The expression of GAL-3 and CK-19 in Hashimoto’s thyroiditis compared to Papillary thyroid carcinoma

  • Murtadha A. Mehdi Department Medical Microbiology and Immunology, College of Medicine, University of Karbala, Karbala, Iraq
  • Ali M. Jasim Department Medical Microbiology and Immunology, College of Medicine, University of Karbala, Karbala, Iraq
  • Mohammed F. Al-Ganber Department Pathology, College of Medicine, University of Karbala, Karbala, Iraq

Abstract

Objective: investigate the hypothesis of that Hashimoto’s thyroiditis (HT) consider risk factor to development Papillary thyroid carcinoma (PTC) and to the compared expression of GAL-3 and CK-19 between groups of diseases that involve in this study.
Methods: 27 Paraffin-embedded tissue of HT submitted to examination by monoclonal antibody to CK-19 and GAL-3 by immunohistochemical test and compared with 24 cases of papillary thyroid carcinoma, 7 PTC with HT and 23 nodular goiters as a control.
Results: high positive expression of both markers in HT and there are non-significant differentiation between HT and PTC when (p > 0.05).
Conclusion: this study concludes that there is etiological relationship between HT and development PTC and GAL-3 may have a role in the cellular transformation to a cancerous cell with PTC feature when continuous overexpression.
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Published
2018-12-26
How to Cite
MEHDI, Murtadha A.; JASIM, Ali M.; AL-GANBER, Mohammed F.. The expression of GAL-3 and CK-19 in Hashimoto’s thyroiditis compared to Papillary thyroid carcinoma. Iraq Medical Journal, [S.l.], v. 2, n. 4, dec. 2018. ISSN 2521-8492. Available at: <http://www.jocms.org/index.php/imj/article/view/528>. Date accessed: 23 mar. 2019.
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Articles