Correlation between c282y mutation of (hfe) gene with high sensitive troponin i in patients of ischemic heart diseases

  • Fadhil Jawad Al-Tu’ma Department of Biochemistry, College of Medicine, University of Kerbala, Holy Kerbala, Iraq.
  • Zainab K Abeid Department of Biochemistry, College of Medicine, University of Kerbala, Holy Kerbala, Iraq.
  • Karim O Al-Naffi Department of Internal Medicine, College of Medicine, University of Kerbala, Holy Kerbala, Iraq.

Abstract

Objective Ischemic heart diseases are the most screen prevalence disease in the world and also diabetic mellitus increases all over the world, both have related to atherogenic lipoprotein modifications. Found the most common C282Y mutation of high ferritin (HFE) gene-related myocardial infarction and unstable angina. The aim of the presented work is to determine whether or not the C282Y mutation in the HFE gene might be correlated with the increased levels of hs-troponin I like a risk index of ischemic heart diseases in diabetic obese patients.Methods A total of 100 individuals were used in this study, which were divided into (ischemic heart disease, diabetic and obese) and control (diabetic and obese) groups. Conducted in the cardiac care unit at Al-Zahra Teaching Hospital / Karbala and Najaf center for heart diseases between Nov. 2015 to Nov. 2016, after genomic DNA of blood extracted, the HFE gene mutation was detected using the PCR–RFLP technique, hs-troponin I, was determined by ELAIS technique.Results The data analysis revealed a significant allele frequency of C282Y mutation among the case groups and controls (P < 0.05). The relationships between the GA and GG genotypes in C282Y mutation in hs-troponin I show a significant difference between the two groups (P = 0.002), lipid profile (TC, TG, LDL-C, HDL-C), Blood Pressure, Body Mass Index (BMI), didn’t show a significant difference between the two groups (P > 0.05). Lipid profile and BMI level were significant difference with independent predictors of IHD (P < 0.05).Conclusion The results revealed a significant correlation between C282Y mutation and development of IHD in obese T2D patients with increasing levels of hs-troponin I.
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Published
2018-09-15
How to Cite
AL-TU’MA, Fadhil Jawad; ABEID, Zainab K; AL-NAFFI, Karim O. Correlation between c282y mutation of (hfe) gene with high sensitive troponin i in patients of ischemic heart diseases. Iraq Medical Journal, [S.l.], v. 2, n. 3, p. 72-78, sep. 2018. ISSN 2521-8492. Available at: <http://www.jocms.org/index.php/imj/article/view/443>. Date accessed: 20 nov. 2018.
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