Controlling the levels of oxidative DNA damage improves patient’s response to simvastatin therapy in primary male infertility

  • Ahmed S. Al-Hilli College of Medicine, University of Kufa, Iraq.
  • Najah A. Hadi Department of Pharmacology, College of Medicine, University of Kufa, Iraq.
  • Ala’a S. Ali Dermatology & Venereology Specialist, Al-Hakeem Hospital, Najaf, Iraq.
  • Dina A. Jamil School of Medicine, Faculty of Health, University of Tasmania, Tasmania, Australia.
  • Hayder A. Al-Aubaidy School of Medicine, Faculty of Health, University of Tasmania, Tasmania, Australia.


Objectives Male primary infertility can occur for several reasons. In most of the cases, sperm sample examination itself may give informationabout the underlying cause, but it would not help in determining the management plan. Simvastatin treatment can help to reduce thedegree of oxidative stress and improve sperm outcome. 8-hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative DNA damage thatcan be used to assess the level of oxidative stress and the patient’s response to a course of treatment.Methods This is a randomized controlled trial study, which included 90 participants (55 males with primary infertility and a matching of 35control subjects). The patients were recruited from Al-Najaf Teaching Hospital, Iraq. Patients were provided with simvastatin tablets (20 mg× once daily for 12 weeks). Semen samples were taken to assess sperm parameters such as morphology, motility and motility. In addition,urinary samples were also collected to measure levels of 8-OHdG, before and after the simvastatin treatment course.Results This study showed significant reduction in the levels of urinary 8-OHdG in the patient group compared to the control group afterthe treatment course.Conclusion This study provides evidence about the beneficial use of simvastatin to improve the sperms’ outcome in males with primaryinfertility. In addition, the useful measurement of urinary 8-OHdG is to monitor the degree of oxidative stress and patient’s response tomedication.
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How to Cite
AL-HILLI, Ahmed S. et al. Controlling the levels of oxidative DNA damage improves patient’s response to simvastatin therapy in primary male infertility. Iraq Medical Journal, [S.l.], v. 2, n. 3, p. 61-63, sep. 2018. ISSN 2521-8492. Available at: <>. Date accessed: 30 sep. 2020.